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Evaluation of latex agglutination test in comparison to culture and counterimmunoelectrophoresis in the diagnosis of bacterial meningitis



Evaluation of latex agglutination test in comparison to culture and counterimmunoelectrophoresis in the diagnosis of bacterial meningitis



Revista do Instituto Adolfo Lutz 55(1): 19-24



About 326 cerebrospinal fluid samples of patients with clinical signs of meningitis were studied through a commercial latex reagent for bacterial antigen detection. The purulent cerebrospinal fluid samples were analysed for Neisseria menigitidis groups B and C, Haemophilus influenzae b. and Streptococcus pneumoniae antigens. The results showed a better performance of the latex agglutination test in comparison to culture for Neisseria menigitidis group B and group C, and for Streptococcus pneumoniae. Except for Streptococcus pneumoniae which was not tested through counterimmunoelectrophoresis, the latex reagent had better performance than counterimmunoelectrophoresis only for Neisseria meningitidis group B. Sensitivity of latex test, as compared with culture, showed highest levels for Neisseria meningitidis group B, and for Streptococcus pneumoniae. When latex test results were compared with counterimmunoelectrophoresis ones, highest levels of sensitivity were observed for Neisseria meningitidis group B and Haemophilus influenzae b. Concerning specificity, fair values were observed for all bacterial agents relating to culture, and for all but Streptococcus pneumoniae which was not tested for counterimmunoelectrophoresis; fair values were also observed when the results of this method were considered. The degree of kappa agreement (k), when compared with culture, exhibited better K indices for Haemophilus influenzae b, and better K indices for this bacterial agent and for Neisseria meningitidis group C as well, when the results of latex agglutination test were compared with counterimmunoelectrophoresis method.

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