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Evaluation of reversed-phase columns for the analysis of very basic compounds by high-performance liquid chromatography: Application to the determination of the tobacco alkaloids


Evaluation of reversed-phase columns for the analysis of very basic compounds by high-performance liquid chromatography: Application to the determination of the tobacco alkaloids



Journal of Chromatography 636(2): 213-220



ISSN/ISBN: 0021-9673

DOI: 10.1016/0021-9673(93)80234-y

A rapid separation of the major tobacco alkaloids with high efficiency and acceptable peak tailing is demonstrated on a RP-HPLC column containing a high-purity silica substrate, without use of silanol masking agents in the eluent. A test procedure based on that of Engelhardt and co-workers, with pyridine as an additional probe compound, was used to aid the selection of a suitable stationary phase from a number of the best commercially available columns for the separation of strongly basic compounds.

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Accession: 008636436

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