+ Translate

Evidence for the involvement of the Wnt 2 gene in human colorectal cancer

, : Evidence for the involvement of the Wnt 2 gene in human colorectal cancer. Oncogene 12(1): 153-158

Colorectal cancer (CRC) is one of the most frequent cancers in humans. It develops via a multistage process involving alterations of both protooncogenes and tumor suppressor genes. In the present report we determined the level of expression of several Wnt genes in CRC by RT-PCR and direct sequencing. While Wnt-1 was not detectably expressed in any colonic tissues, Wnt-5a gene was efficiently expressed both in nontumorous as well as in colonic tumor tissues. In contrast, the Wnt-2 gene, which was expressed at low levels in normal colon, exhibited overexpression in all tumor tissue samples at the different Dukes' stages of CRC progression, including premalignant polyps and liver metastases. Overexpression of the Wnt-2 gene occurred also in other digestive neoplasms such as gastric and esophageal carcinomas, as well as in diverticulitis associated with stenosis or pseudo-tumor.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 008643151

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Bridges, Bryn A., 1998: The role of DNA damage in stationary phase mutation. Mutation Research 408(1): 1-9, July

Dome, J. S.; Perlman, E. J.; Adey, C.; Carey, L. A.; Umbricht, C. B.; Varon, D.; Sukumar, S., 1997: Telomerase activity as a predictor of relapse in Wilms tumor. Proceedings of the American Association for Cancer Research Annual Meeting 38(0): 505

Bryanskiy L. I., 1992: Problems in studying magma chamber-type ore regions. Pages 20-26 1992

Gowing, D. P.; Leeper, R. W., 1961: Studies on the relation of chemical structure to plant growth-regulator activity in the pineapple plant. IV. Hydrazine derivatives, compounds with an unsaturated aliphatic moiety and miscellaneous chemicals. Six hydrazine derivatives were found to induce flowering in pineapple plants, although two of these were not active in all tests. Acetylene, ethylene and propylene were the only unsaturated aliphatic acids to induce flowering. Some compounds suppr...

Franz, H.; Weiss, E., 1981: Zur Kenntnis der Okologie der alpinen Verbreitungsgrenze heliophiler Arthropoden. Veroeffentlichungen des Oesterreichischen Mass-Hochgebirgsprogramms Hohe Tauern, 4: 237-246

Sass, Bruce M., 2001: Analysis of corrosion compounds associated with PRBS and their impact on barrier longevity. Abstracts of Papers American Chemical Society 221(1-2): ENVR 167

Anonymous, 2012: Thymoquinone Novel gastroprotective mechanisms. Ample of evidence proved the gastroprotective effect of thymoquinone (TQ), the main constituent of <italic>Nigella sativa</italic> oil; however, the full mechanistic cassette on the gastric ulcer etiopathogenesis is not fully elucidate...

Boutaleb, N.; Ouhabi, H.; Bourazza, A.; Mosseddaq, R., 2000: Posterior interosseous syndrome. Study of three cases. We report three cases of posterior interosseous syndrome. It is a purely motor paralysis without sensory deficit which affects, at different degrees, the extensor digitorum communis, the extensor pollicis and the extensor carpi ulnaris. The diagno...

Forte, V., 1962: The apricots of Vesuvius. Details are given of apricot cultivation in the province of Naples, which accounts for some 80% of the production of the whole of Italy. Innumerable cultivars exist, most of them having originated from growers planting their own seed. Data are pre...

Anonymous, 2013: Novel signatures of cancer associated fibroblasts. Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer associated fibroblasts, in cancer development and progression. In this study we developed a novel, visually based method to identify new immunohistoch...