+ Translate

Experimental mandibular regrowth by distraction osteogenesis: Long-term results

, : Experimental mandibular regrowth by distraction osteogenesis: Long-term results. Archives of Otolaryngology Head and Neck Surgery 119(5): 511-516

The use of gradual distraction to grow bone (distraction osteogenesis) has gained widespread orthopedic acceptance, but has only recently been applied to craniofacial skeletal defects. The use of bifocal distraction osteogenesis to fill experimental segmental mandibular defects with regenerate bone was recently reported. Though all canines in that study demonstrated normal oromandibular function, they were observed for only 4 weeks following defect closure. The study that is now reported describes the long-term (12-month) functional, morphologic, and biomechanical results when bifocal distraction osteogenesis was applied to the same model. In this long-term study, three canines had 2.5-cm unilateral segmental mandibular body defects filled with structurally stable bone using bifocal distraction osteogenesis. These dogs exhibited normal oromandibular function for 1 year following segment regrowth and external fixator removal. Macroscopic and histologic evaluation of the regrown segments revealed a re-formation of the cortical and medullary architecture. Stress testing demonstrated the average ultimate strength of the regrown segment at 53 MPa, which corresponded to 77% +- 5.7% of normal mandibular bone. The data suggest that clinical trials applying this technique to segmental mandibular reconstruction are warranted.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 008652878

DOI: 10.1001/archotol.1993.01880170035007

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Harryman, M. B. M., 1993: Water source protection and protection zones. The UK government policy to August 1989 on the use of protection zones to protect water sources from pollution by nitrate is discussed. The background to the current UK policy on the control of nitrate is examined and the factors influencing the d...

Copin, A; Martens, Ph; Kettmann, R; Closset, Jl; Duculot, C., 1975: Application of total attenuated spectrometry in infrared andvisible lights to the study of antigerminative residues (propham and chlorpropham) on potato tubers. Analytica chimica acta: 74 (2) 437-440

Hulsmann W.C.; Dubelaar M L., 1986: Lipoprotein lipases and stress hormones studies with glucocorticoids and cholera toxin. The intravenous injection of cholera toxin in rats 17 h prior to experimentation results in increased levels of insulin and corticosterone in the blood. This is accompanied by a rise in lipoprotein lipase activity in muscle and a decrease in adipo...

Villet, Rh; Dalziel, K., 1969: Purification and properties of t-phosphogluconate dehydrogenase from sheep liver. Bio chemical journal: 115 (4) 639-643

Shopov V., 1984: Biostratigraphy of the upper quaternary deposits from the southwest sector of the black sea. The benthic molluscan fauna does not play a decisive role in the stratigraphy of the deep sea deposits. The low boundary of its distribution coinsides with the outer boundary of the shelf which is situated at depths of 150-200 m. At greater depths...

G. Selvakumar; S. Kundu; Anand D. Gupta; Yogesh S. Shouche; Hari S. Gupta, 2008: Isolation and characterization of nonrhizobial plant growth promoting bacteria from nodules of Kudzu (Pueraria thunbergiana) and their effect on wheat seedling growth. The leguminous vine Kudzu (Pueraria thunbergiana) is an introduction into the N. W. Himalayan region of India. Despite its value as a fodder and cover crop, little is known about the nature of the nodule microflora. In an attempt to study the nodu...

Deng You Ping; Lin Chen; Chen Jie Ping; Liang Xiao; Chen De Quan; Xiao Pei Gen; Wu Min, 1999: Arsenic trioxide induced human cervical cancer cell apoptosis and effect of bcl-2 overexpression on it. Lipofectin mediated DNA transfection, MTT reduction, clone forming assay, flowcytometric analysis and in situ cell death detection were used to study the biological effect of As2O3 on human cervical cancer SiHa and HeLa cells and the protection by...

Nursall, JR.; Maisey, JG., 1991: Neoproscinetes Figueiredo and Silva Santos, 1987. Unknown

Salehzadeh,S.; Daneshvar,M.H.; Moallemi,N., 2008: Indirect organogenesis from scale, leaf primordia and immature floret explants of hyacinth. American Eurasian Journal Of Agricultural And Environmental Science: 5, Unpaginated

Thomas, E. A.; Dean, B.; Pavey, G.; Scarr, E.; Sutcliffe, J. G., 2001: Apolipoprotein D as a region-specific marker for schizophrenia. We have previously demonstrated that, although apolipoprotein D (apoD) levels are diminished in serum from patients with schizophrenia, they are elevated in the dorsolateral prefrontal cortex and caudate of both schizophrenic and bipolar subjects,...