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Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-galactosamine



Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-galactosamine



Biochemical and Biophysical Research Communications 220(2): 285-288



We reported recently that heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is a new hepatotrophic factor for the regeneration of rat liver after partial hepatectomy. The current study examined changes in the amount of HB-EGF mRNA in liver injured by hepatotoxins. The level of HB-EGF mRNA was very low in normal rat liver, but increased markedly in the liver of rats injured by CCl-4, showing two peaks, the first at 6 h and the second at 36 h. Western blot analysis showed that HB-EGF protein in the liver of CCl-4,-treated rats (at 6 h) was increased about 3.4-fold above normal. The level of HB-EGF mRNA also increased markedly in the liver of rats treated with D-galactosamine, showing a major peak at 18 h, and a smaller one at 6 h. These results indicate that HB-EGF may play a role in the regeneration of the liver following hepatotoxic injury.

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Accession: 008661054

Download citation: RISBibTeXText

PMID: 8645297

DOI: 10.1006/bbrc.1996.0397



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