Expression of human recombination activating genes (RAG-1 and RAG-2) in Hodgkin's disease
Knecht, H.; Joske, D.J.; Eméry-Goodman, A.; Bachmann, E.; Bachmann, F.; Odermatt, B.F.
Blood 80(11): 2867-2872
ISSN/ISBN: 0006-4971 PMID: 1450411 DOI: 10.1182/blood.v80.11.2867.2867
The differentiation status of Sternberg-Reed (SR) cells is still not well defined, primarily because of their scarcity in tumor biopsies of Hodgkin's disease (HD). In this study we have determined the genomic differentiation status of SR cells by quantitation of recombinase activating gene (RAG) expression. RAG genes are selectively transcribed in immature lymphoid cells.