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Factors which alter the relationship between ventilation and carbon dioxide production during exercise in normal subjects



Factors which alter the relationship between ventilation and carbon dioxide production during exercise in normal subjects



European Journal of Applied Physiology and Occupational Physiology 73(1-2): 144-148



The slope of the linear relationship between ventilation ( ovrhdot V-E) and carbon dioxide production ( ovrhdot VCO-2) has been thought to indicate that ovrhdot VCO-2 is one of the major stimuli to ovrhdot V-E. A group of 15 normal subjects undertook different incremental treadmill exercise protocols to explore the relationship between ovrhdot E and ovrhdot VCO-2. An incremental protocol using 1 instead of 3-min stages of exercise resulted in an increase in the ovrhdot V-E to ovrhdot VCO-2 ratio (26.84 (SEM 1.23) vs 31.08 (SEM 1.36) (P lt 0.008) for the first stage, 25.24 (SEM 0.86) vs 27.83 (SEM 0.91) (P lt 0.005) for the second stage and 23.90 (SEM 0.86) vs 26.34 (SEM 0.81) (P = 0.001) for the third stage). Voluntary hyperventilation to double the control level of ovrhdot V-E during exercise resulted in an increase in the VE to ovrhdot VCO-2 slope (from 21.3 (SEM 0.71) for the control run to 35.1 (SEM 1.2) for the hyperventilation run (P lt 0.001)). Prolonged hyperventilation (5 min) during exercise at stage 2 of the Bruce protocol resulted in a continued elevation of ovrhdot CO-2 and the ovrhdot V-E/ ovrhdot VCO-2 slope. A steady state of ovrhdot V-E and metabolic gas exchange can only be said to have been present after at least 3 min of exercise. Voluntary hyperventilation increased the slope of the relationship between ovrhdot V-E and ovrhdot VCO-2. End-tidal carbon dioxide fell, but remained within the normal range. These results would suggest that a non-carbon dioxide factor may have been responsible for the increase we found in PE during exercise, and that factors other than increased dead space ventilation can cause an increased ventilation to ovrhdot VCO-2 slope, such as that seen in some pathophysiological conditions, such as chronic heart failure.

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Accession: 008674041

Download citation: RISBibTeXText

PMID: 8861683

DOI: 10.1007/bf00262823


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