+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Formoterol and salmeterol are both long acting compared to terbutaline in the isolated perfused and ventilated guinea-pig lung



Formoterol and salmeterol are both long acting compared to terbutaline in the isolated perfused and ventilated guinea-pig lung



European Journal Of Pharmacology. 257(1-2): 137-143



An isolated, perfused and ventilated guinea-pig lung was used to compare the duration of effect of the bronchodilating beta-2-adrenoceptor agonists formoterol, salmeterol and terbutaline. Lung conductance was measured real time with the aid of a computer. Bronchoconstriction was induced in the preparation every 10 min by bolus injections of acetylcholine into the pulmonary artery. Lung conductance was reduced by about 70% after acetylcholine. The test compounds or the vehicle was administered for 1 min as aerosols generated from solutions: formoterol (10 mu-mol/l), salmeterol (100 mu-mol/l) and terbutaline (1000 mu-mol/l). This treatment inhibited the response to acetylcholine by 50-60% within the first 10 min for all three test compounds. The onset of action appeared to be slower for salmeterol than for formoterol and terbutaline. The inhibitory effect of terbutaline disappeared completely during the next 20 min of continuous perfusion (single pass), while both formoterol and salmeterol displayed a significant inhibitory effect 40 min after their administration. Formoterol, when inhaled at a higher dose (100 mu-mol/l), caused a 90% inhibition of the response to acetylcholine. This effect was completely reversed by 0.1 mu-mol/l propranolol in the perfusion medium. There were in general no major changes in the basal conductance measured between the acetylcholine provocations.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008700821

Download citation: RISBibTeXText

PMID: 8082695

DOI: 10.1016/0014-2999(94)90705-6


Related references

Duration of effect of inhaled formoterol compared with salmeterol and terbutaline in the isolated perfused and ventilated guinea-pig lung. Acta Physiologica Scandinavica Supplementum 0(608): 110, 1992

Onset of action and duration of effect of formoterol and salmeterol compared to salbutamol in isolated guinea pig trachea with or without epithelium. Allergy 47(4 PART 2): 384-387, 1992

Why use long acting bronchodilators in chronic obstructive lung diseases? An extensive review on formoterol and salmeterol. European Journal of Internal Medicine 26(6): 379-384, 2016

Short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols; the detailed pharmacokinetics of budesonide, formoterol, and terbutaline. Journal of Aerosol Medicine and Pulmonary Drug Delivery 21(2): 169-180, 2008

Long-acting bronchodilators (formoterol and salmeterol) for treatment of asthma. Pneumologie 63(4): 195-196, 2009

Salmeterol and formoterol are they both long acting beta 2 adrenoceptor agonists. British Journal of Pharmacology 99(PROC SUPPL APRIL): ABSTRACT 120P, 1990

Sulfur Dioxide-Induced Bronchoconstriction in the Isolated Perfused and Ventilated Guinea-Pig Lung. Respiration 59(1): 16-21, 2009

Sulfur dioxide-induced bronchoconstriction in the isolated perfused and ventilated guinea-pig lung. Respiration; International Review of Thoracic Diseases 59(1): 16-21, 1992

Characterization of bronchodilator effects and fate of S-nitrosothiols in the isolated perfused and ventilated guinea pig lung. Journal of Pharmacology and Experimental Therapeutics 272(3): 1238-1245, 1995

Hydrogen peroxide-induced broncho- and vasoconstriction in the isolated perfused and ventilated guinea pig lung. Pharmacology & Toxicology. 72(4-5): 314-320, 1993

Kinetic analysis of drug-receptor interactions of long-acting beta2 sympathomimetics in isolated receptor membranes: evidence against prolonged effects of salmeterol and formoterol on receptor-coupled adenylyl cyclase. Journal of Pharmacology and Experimental Therapeutics 288(3): 1084-1092, 1999

Long acting inhaled beta-adrenoceptor agonists the comparative pharmacology of formoterol and salmeterol. Agents and Actions. Supplements 43: 253-269, 1993

Quality of life in patients treated with two long-acting beta2-agonists Formoterol and salmeterol. European Respiratory Journal Supplement 10(25): 3S, Sept, 1997

Hexamethylene diisocyanate (HDI)-induced lung impairment: Studies in isolated perfused and ventilated guinea pig lungs. Pharmacology and Toxicology 81(2): 85-89, 1997

Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. Journal of Pharmacology and Experimental Therapeutics 307(1): 408-418, 2003