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Free methionine supplementation limits alcohol-induced liver damage in rats



Free methionine supplementation limits alcohol-induced liver damage in rats



Alcoholism Clinical and Experimental Research 22(2): 352-358



Alcohol feeding to rats that were submitted to a jejunoileal bypass operation has been shown to result in liver damage being comparable with alcohol-induced liver disease in man. In the present study, a striking effect of free methionine consumption on histological liver injury, triglyceride accumulation, and energy-rich nucleoside content in the liver of rats with a jejunoileal bypass is demonstrated. The animals obtained 0, 30, and 120 mg of methionine in the control group and 0, 30, 120, and 240 mg in the alcohol-fed group per day and per kilogram of body weight for 12 weeks. Methionine was found to strongly improve the alcohol-induced histological changes in the liver. Triglyceride content of the liver was found to decrease in a dose-dependent manner with increasing methionine ingestion (from 255 +- 20.7 to 49.7 +- 6.1 pmol/g of protein in the control group and from 233 +- 17.3 to 42.1 +- 7.2 mumol/g of protein in the alcohol group). Hepatic adenosine triphosphate content increased significantly with higher methionine consumption (13.5 +- 0.8 vs. 26.9 +- 2.8 mumol/g of protein in the control group and 11.9 +- 1.4 vs. 20.5 +- 2.5 pmol/g of protein in the alcohol group), whereas no differences were found in the protein and DNA content of the liver. These results underscore the impairment of the transmethylation/transsulfuration pathway in the development of alcohol-induced liver diseases.

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Accession: 008703414

Download citation: RISBibTeXText

PMID: 9581640

DOI: 10.1111/j.1530-0277.1998.tb03660.x


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