Section 9
Chapter 8,710

Functional domains of human TIMP-1 (tissue inhibitor of metalloproteinases)

Bodden, M.K.; Harber, G.J.; Birkedal-Hansen, B.; Windsor, L.J.; Caterina, N.C.; Engler, J.A.; Birkedal-Hansen, H.

Journal of Biological Chemistry 269(29): 18943-18952


ISSN/ISBN: 0021-9258
PMID: 7518446
Accession: 008709432

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To define domains of tissue inhibitor of metalloproteinases (TIMP-1) that are important to its ability to inhibit fibroblast-type collagenase (FIB-CL), two different approaches were used: (i) competition with synthetic peptides modeled after the human TIMP-1 sequence and (ii) localization of epitopes of blocking antibodies. TIMP-1 consists of six loops, held in place by six disulfide bonds arranged in three knotlike structures.

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