Functionalization of nucleoside analogs: regiospecific conversion of 4"-hydroxyl groups to thioesters and deoxygenation of 3'-hydroxyl groups
Huang, Z.; Benner, S.A.
Nucleosides and Nucleotides 17(5): 895-899
1998
ISSN/ISBN: 0732-8311 PMID: 9708330 Accession: 008711720
Nucleoside analogs 3a-e were conveniently functionalized by regiospecifically converting 4"-hydroxyl groups to thioesters 4a-e (>90% yield) and reducing 3'-hydroxyl groups to give building blocks 2a-e in 85-90% yields.
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