+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Genetic predisposition to coronavirus-induced retinal disease

Genetic predisposition to coronavirus-induced retinal disease

Investigative Ophthalmology & Visual Science 37(1): 250-254

Purpose: Retinal inflammatory and degenerative processes in humans and animals frequently are associated with genetic factors. The murine coronavirus, mouse hepatitis virus (MHV), JHM strain, induces a biphasic retinal disease in adult BALB/c mice. The genetic constitution of the host and the virus serotype can be critical factors in determining the outcome of a virus infection. The purpose of this study was to evaluate the possible role of host genetics in murine coronavirus-induced retinal disease. Methods: JHM virus was inoculated by the intravitreal route into BALB/c, CD-1, and A/J mice. At varying times after inoculation, eye tissues were evaluated histologically. Antibody responses to the virus were evaluated by neutralization assays. Results: JHM virus induces a biphasic retinal disease in BALB/c mice. In the early phase, 1 to 7 days after inoculation, retinal vasculitis is observed. The second phase, characterized by retinal degeneration in the absence of inflammation, is seen by day 10 and progresses for several months. There is a similar biphasic disease process in JHM virus-infected A/J mice. However, retinal changes are less severe than those seen in BALB/c mice. Retinal tissue damage induced by JHM virus in CD-1 mice is different. Only the early phase of the disease, consisting of retinal vasculitis, was observed. These CD-1 mice do not develop the retinal degenerative disease. In fact, after day 10, the retina has a normal appearance. These differences in retinal tissue damage are seen over a wide range of infectivity of the virus inocula. Virus concentrations ranging from 10-1.4 to 10-4.4 TCID-50/5 mu-l were capable of inducing both inflammation and degeneration in BALB/c mice, whereas, the highest concentration of virus (10-4.4 TCID-50/5 mu-l) in CD-1 mice resulted in only the early inflammatory changes. Conclusions: The authors show that the genetics of the host can profoundly affect the nature of retinal tissue damage. These studies substantiate the concept that a virus can indeed trigger retinal degenerative processes in genetically susceptible hosts.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 008728791

Download citation: RISBibTeXText

PMID: 8550331

Related references

Simple and complex ABCR: genetic predisposition to retinal disease. American Journal of Human Genetics 67(4): 793-799, 2000

Genetic predisposition to drug-induced liver disease. Gastroenterology Clinics of North America 24(4): 811-838, 1995

Focal epithelial hyperplasia: human-papillomavirus-induced disease with a genetic predisposition in a Venezuelan family. Human Genetics 91(4): 386-388, 1993

Retinal vein occlusion: genetic predisposition and systemic risk factors. Blood Coagulation and Fibrinolysis 24(3): 279-283, 2013

The 43rd Scientific Meeting: Perspectives of Internal Medicine; Genetic predisposition and related life-style underlying metabolic disorders: 2. Genetic and Environmental Susceptibility; 1) The predisposition to impaired glucose metabolism. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 105(3): 367-375, 2016

What do the terms "genetic predisposition" and "genetic heterogeneity" mean in relation to inflammatory bowel disease?. Inflammatory Bowel Diseases 14(Suppl. 2): S31-S32, 2008

A parallel genetic algorithm to discover patterns in genetic markers that indicate predisposition to multifactorial disease. Computers in Biology and Medicine 38(7): 826-836, 2008

Immunologic factors in the pathogenesis of coronavirus induced retinal diseases. Abstracts of the General Meeting of the American Society for Microbiology 97: 541, 1997

Retinal disease in mice following intravitreal injection of a murine coronavirus. Investigative Ophthalmology & Visual Science 30(3 Suppl.): 363, 1989

Retinal apoptosis is associated with clearance of infectious virus in coronavirus-induced retinopathy. IOVS 39(4): S148, 1998

Genetic and auto-immune features of pernicious anemia. 1. Unreliability of the Schilling test in detecting genetic predisposition to the disease. Johns Hopkins Med. J 122: 181-183, 1968

A large Canadian kindred with Wagners Disease, a predisposition to retinal detachments. IOVS 39(4): S298, 1998

Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece. Atherosclerosis 222(1): 175-179, 2012

Genetic predisposition to gold induced and penicillamine induced drug toxicity. Scandinavian Journal of Rheumatology Suppl. (33): 15, 1980