Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase) , and concomitantly PI3-kinase activation via JAK2 kinase
Yamauchi, T.; Kaburagi, Y.; Ueki, K.; Tsuji, Y.; Stark, G.R.; Kerr, I.M.; Tsushima, T.; Akanuma, Y.; Komuro, I.; Tobe, K.; Yazaki, Y.; Kadowaki, T.
Journal of Biological Chemistry 273(25): 15719-15726
Growth hormone (GH) and prolactin (PRL) binding to their receptors, which belong to the cytokine receptor superfamily, activate Janus kinase (JAK) 2 tyrosine kinase, thereby leading to their biological actions. We recently showed that GH mainly stimulated tyrosine phosphorylation of epidermal growth factor receptor and its association with Grb2, and concomitantly stimulated mitogen-activated protein kinase activity in liver, a major target tissue.