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Heavy metals and the mammalian thymus: In vivo and in vitro investigations

Ficek, W.

Toxicology and Industrial Health 10(3): 191-201

1994

ISSN/ISBN: 0748-2337
PMID: 7855868
DOI: 10.1177/074823379401000308
Accession: 008760185
This experiment was performed to investigate changes in the thymus of Wistar-strain male rats administered cadmium chloride (CdCl-2), mercuric chloride (HgCl-2), and lead chloride (PbCl-2) salts. The study involved measurement of: 1) deoxyribonucleic acid (DNA) content; 2) ascorbic acid (vitamin C) content; 3) incorporation of 3H-thymidine during in-vitro investigation; and 4) histological and morphological changes. It was shown in investigations on DNA content that administration of heavy metal salts caused an average 76% decrease in DNA content compared to the control. Moreover, in the thymus of experimental animals, an average 69% decrease in vitamin C content was recorded. In in vitro cultures, heavy metal salts decreased the incorporation of 3H-thymidine in thymic cells.

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