+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hepatic function during short-term total parenteral nutrition: effect of exposure of parenteral nutrients to light



Hepatic function during short-term total parenteral nutrition: effect of exposure of parenteral nutrients to light



Research Communications in Chemical Pathology and Pharmacology 78(3): 321-340



Total parenteral nutrition (TPN) solutions either exposed to light (+L) or protected from light (-L) were infused for 5 days through jugular cannulas in freely moving rats placed in metabolic cages. At the end of the 5 day period, bile flow, biliary inorganic phosphate and biliary gamma-glutamyl transferase activity, as well as biliary concentrations of several essential and branch chain amino acids were significantly lower in the -L animals compared to +L animals. In addition, biliary glutathione was significantly lower in the +L animals. In both groups of animals, plasma tyrosine decreased significantly from pre-TPN values despite a doubling of plasma phenylalanine concentrations suggesting that tyrosine may become a conditionally essential amino acid in rats provided TPN. Our findings indicate that short-term parenteral infusion of light exposed TPN solutions alters hepatobiliary function as well as amino acid homeostasis and that the changes are minimized by light protection of the infusates. The exact mechanisms of the contribution of light exposure in the induction of hepatic dysfunction remain to be elucidated.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008764581

Download citation: RISBibTeXText

PMID: 1362005


Related references

The effect of short-term total parenteral nutrition on hepatic function in the human neonate: a prospective randomized study demonstrating alteration of hepatic canalicular function. Journal of Pediatrics 99(3): 445-449, 1981

Effect of short term parenteral nutrition on hepatic function in the human neo nate. Clinical Research 28(5): 856A, 1980

Altered hepatic function in rats after light exposure of parenteral nutrients. Clinical Research 38(1): 44A, 1990

Effect of taurine supplementation on hepatic function during short-term parenteral nutrition in the premature infant. Journal of Pediatric Gastroenterology and Nutrition 3(2): 234-238, 1984

Thyroid function on short-term total parenteral nutrition without iodine supplements. Jpen. Journal of Parenteral and Enteral Nutrition 6(5): 439-440, 1982

Hepatic organic anion transport kinetics and bile flow during short-term total parenteral nutrition in the rabbit. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 195(2): 274-278, 1990

Total parenteral nutrition-associated alterations in hepatobiliary function and histology in rats: is light exposure a clue?. Pediatric Research 33(5): 487-492, 1993

The Role of Parenteral Lipids in the Development of Hepatic Dysfunction and Hepatic Steatosis in a Mouse Model of Total Parenteral Nutrition. Journal of Nutritional Science and Vitaminology 65(1): 24-30, 2019

Effect of decreased parenteral soybean lipid emulsion on hepatic function in infants at risk for parenteral nutrition-associated liver disease: a pilot study. Journal of Pediatric Surgery 48(6): 1348-1356, 2013

Storage of mixtures for total parenteral nutrition--long-term stability of a total parenteral nutrition mixture. Journal of Clinical and Hospital Pharmacy 8(3): 265-274, 1983

Effect of short term total parenteral nutrition on cholesterol and liver enzymes. FASEB Journal 12(4): A250, 1998

The Use of Parenteral Nutrition Support in an Acute Care Hospital and the Cost Implications of Short-term Parenteral Nutrition. Annals of the Academy of Medicine Singapore 45(6): 237-244, 2016

Peripheral parenteral nutrition: an option for patients with an indication for short-term parenteral nutrition. Nutricion Hospitalaria 19(1): 14-18, 2004

Consultative total parenteral nutrition teams: the effect on the incidence of total parenteral nutrition-related complications. Jpen. Journal of Parenteral and Enteral Nutrition 8(2): 146-152, 1984

Effect of short-term octreotide therapy and total parenteral nutrition on the development of biliary sludge and lithiasis. Hepato-Gastroenterology 49(45): 609-612, 2002