+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

High-dose intravenous immunoglobulins in neurocritical care



High-dose intravenous immunoglobulins in neurocritical care



Intensivmedizin und Notfallmedizin 32(8): 642-650



High-dose intravenous human immunoglobulin G (IVIG) is a well-tolerated, rapidly acting immunodepressant, effective in neuroimmunological diseases. Side effects appear rare. A Dutch controlled study showed that in Guillain-Barre syndrome IVIG is at least as effective as plasma exchange (PE). Three controlled and randomized studies are being performed comparing IVIG with PE, with immunoadsorption, with a combination of PE followed by IVIG, and with IVIG given together with methylprednisolone. In dermatomyositis and in polymyositis IVIG is beneficial, especially in cases resistant to conventional treatment. In inclusion body myositis IVIG is the only treatment promising to work, and in multifocal motor neuropathy IVIG is an alternative to conventional cyclophosphamide. Mild to severe deterioration in myasthenia gravis is treated effectively with IVIG, which may act more rapidly than corticosteroids and may cause less worsening of pareses. A controlled randomized trial is being carried out. In life-threatening myasthenic crisis conventional PE should be the therapy of first choice until the results of a study comparing IVIG and PE are published. An unknown risk of human plasma preparations cannot be completely excluded, especially regarding spongioform encephalopathies such as Creutzfeld-Jacobs's disease. Therefore the administration of IVIG should be restricted to severely affected patients.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008773812

Download citation: RISBibTeXText


Related references

High-dose intravenous immunoglobulins. Journal of Perinatal Medicine 24(5): 539, 1996

The use of high dose intravenous immunoglobulins in dermatology. Journal der Deutschen Dermatologischen Gesellschaft 1(3): 183-190, 2003

Use of high dose intravenous immunoglobulins in dermatology. Journal der Deutschen Dermatologischen Gesellschaft 8(5): 386-7; Author Reply 387-9, 2010

High dose subcutaneous unfractionated heparin for prevention of venous thromboembolism in overweight neurocritical care patients. Journal of Thrombosis and Thrombolysis 40(3): 302-307, 2015

Use of high-dose intravenous immunoglobulins in pediatric hematology. La Pediatria Medica e Chirurgica 16(1): 37-41, 1994

Side effects of high-dose intravenous immunoglobulins. Clinical Neuropharmacology 20(5): 385-393, 1997

Infection prevention strategies in a stem cell transplant unit: impact of change of care in isolation practice and routine use of high dose intravenous immunoglobulins on infectious complications and transplant related mortality. European Journal of Haematology 83(2): 130-138, 2009

The use of high-dose intravenous immunoglobulins in Guillain-Barré syndrome. Anaesthesia 47(3): 220-222, 1992

Dermatomyositis treated with high-dose intravenous immunoglobulins and associated with panniculitis. Clinical & Experimental Dermatology. 20(2): 164-167, 1995

High-dose intravenous immunoglobulins Adverse reactions in 125 patients with ITP. British Journal of Haematology 102(1): 363, 1998

Aseptic meningitis during treatment with high-dose intravenous immunoglobulins. Presse Medicale 25(13): 643, 1996

Known and potential risks related to the use of high dose intravenous immunoglobulins. Annales de Dermatologie et de Venereologie 124(5): 381-383, 1997

Mechanisms of high-dose intravenous immunoglobulins in demyelinating diseases. Archives of Neurology 56(6): 661-663, 1999

Immunomodulation in myasthenia gravis by high dose intravenous 7 s immunoglobulins. Drachman, D B (Ed ) Annals Of The New York Academy Of Sciences, Vol 505 Myasthenia Gravis: Biology And Treatment; Seventh International Conference, New York, New York, Usa, March 4-7, 1986 Xvii+914p The New York Academy Of Sciences: New York, New York, Usa Illus 828-831, 1987

High dose intravenous immunoglobulins in guillain barre syndrome. Revue Neurologique (Paris) 145(10): 731-732, 1989