EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Higher high density lipoprotein cholesterol associated with moderate alcohol consumption is not related to altered plasma lecithin: Cholesterol acyltransferase and lipid transfer protein activity levels



Higher high density lipoprotein cholesterol associated with moderate alcohol consumption is not related to altered plasma lecithin: Cholesterol acyltransferase and lipid transfer protein activity levels



Clinica Chimica Acta 258(1): 105-115



Lecithin:cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) are important factors involved in HDL metabolism. Altered plasma activity levels of these factors could play a role in the increase in high density lipoprotein (HDL) cholesterol associated with moderate alcohol consumption. We measured plasma LCAT, CETP and PLTP activities with exogenous substrate assays, as well as lipoproteins and HDL lipids in 6 alcohol-abstaining men, 18 matched men who used < or = 1 and 18 men who used > or = 1 alcohol-containing drinks per day. Plasma cholesterol and triglycerides were similar in the three groups. HDL total cholesterol, HDL cholesteryl ester, HDL free cholesterol and HDL triglycerides were higher in the alcohol drinkers compared to the abstainers (all P < 0.05). No differences in plasma LCAT, CETP and PLTP activity levels were observed between the three groups. Analysis of covariance also demonstrated that the use of alcohol was associated with higher HDL cholesterol (P < 0.04), whereas plasma LCAT, CETP and PLTP activity levels were not related to alcohol consumption. Furthermore, HDL cholesteryl ester was positively associated with LCAT activity (P < 0.001), PLTP activity (P < 0.01) and alcohol intake (P < 0.04) and negatively with plasma triglycerides (P < 0.001) and CETP activity (P < 0.03); indicating that alcohol influenced HDL cholesteryl ester independently from these biochemical parameters. The higher HDL cholesterol associated with moderate alcohol consumption is, therefore, unlikely to be caused by and effect on plasma LCAT, CETP or PLTP activity levels.

(PDF emailed within 0-6 h: $19.90)

Accession: 008775869

Download citation: RISBibTeXText

PMID: 9049447

DOI: 10.1016/s0009-8981(96)06451-0



Related references

The role of altered high-density lipoproteins in the low plasma lecithin cholesterol acyltransferase and lipid transfer protein activity found in growth hormone-deficient men with acromegaly. Growth Hormone & IGF Research 10(Supplement B): 144, April, 2000

Effects of alcohol on lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, and lecithin:cholesterol acyltransferase in high-density lipoprotein cholesterol elevation. Atherosclerosis 111(1): 99-109, 1994

Low plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone deficient and acromegalic men: Role in altered high density lipoproteins. Atherosclerosis 153(2): 491-498, December, 2000

Low plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone deficient and acromegalic men: role in altered high density lipoproteins. Atherosclerosis 153(2): 491-498, 2001

D-galactosamine induced hepatitis in the rabbit: effect on lecithin:cholesterol acyltransferase activity, plasma lipid transfer protein activity and high density lipoproteins. Comparative Biochemistry and Physiology. B, Comparative Biochemistry 85(3): 659-667, 1986

Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia. Atherosclerosis 106(2): 191-201, 1994

Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia. Atherosclerosis 106(2): 191-201, 1994

Lecithin cholesterol acyltransferase activity in relation to plasma and high density lipoprotein lipid concentrations in the domestic pig sus scrofa domesticus. Comparative Biochemistry & Physiology B 81(2): 531-534, 1985

Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease. Acta Medica Scandinavica 222(1): 23-26, 1987

α-Lecithin: Cholesterol Acyltransferase Deficiency : Lack of Both Phospholipase A2 and Acyltransferase Activities Characteristic of High Density Lipoprotein Lecithin: Cholesterol Acyltransferase in Fish Eye Disease. Journal of Internal Medicine 222(1): 23-26, 1987

Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins. European Journal of Clinical Investigation 33(12): 1051-1069, 2003

High-density lipoprotein cholesterol is related to the TaqIB cholesteryl ester transfer protein gene polymorphism and smoking, but not to moderate alcohol consumption in insulin-dependent diabetic men. Scandinavian Journal of Clinical and Laboratory Investigation 58(3): 251-258, 1998

Low levels of high-density lipoprotein cholesterol due to lecithin:cholesterol acyltransferase mutations increase carotid atherosclerosis. Journal of the American College of Cardiology 58(24): 2488-2490, 2012

Lecithin-cholesterol acyltransferase activity and lipid composition of high density lipoprotein subfractions in hyperalphalipoproteinemia. Voprosy Meditsinskoi Khimii 26(3): 365-370, 1980

Molecular Mechanism of Reverse Cholesterol Transport: Reaction of Pre-b-Migrating High-Density Lipoprotein with Plasma Lecithin/Cholesterol Acyltransferase. Biochemistry (American Chemical Society) 43(46): 811-20, 2004