EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Higher rate of multiple births after periconceptional multivitamin supplementation



Higher rate of multiple births after periconceptional multivitamin supplementation



Orvosi Hetilap 137(43): 2401-2405



A randomized controlled trial of periconceptional multivitamin supplementation including 0.8 mg folic acid was carried out for at least 28 days before conception. The trial was continued until at least until the second missed menstrual period to test the effectiveness of this new primary preventive method in the reduction of neural tube defects. However, other pregnancy outcomes were also evaluated. Of total of 5,502 pregnant women, 4,846 births were analysed in the final data base. The rate of multiple births was significantly higher in the multivitamin group (3.8%) than in the placebo-like trace-element control group (2.7%), and in both groups exceeded the multiple birth rate of 2.2% of women in the Hungarian population at large. 7.3% of women in the multivitamin and 7.9% of women in the trace-element groups received ovarian stimulation treatment (mainly clomiphen) for hormonal dysfunctions, e. g. anovulation. Nonetheless, our study showed that periconceptional multivitamin supplementation, with or without stimulation, increases the rate of multiple births.

(PDF emailed within 1 workday: $29.90)

Accession: 008775941

Download citation: RISBibTeXText



Related references

The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causes. Acta Geneticae Medicae et Gemellologiae 43(3-4): 175-184, 1994

The higher rate of multiple birth after periconceptional multivitamin supplementation. European Journal of Human Genetics 6(SUPPL 1): 73, 1998

Higher rate of multiple births after periconceptional vitamin supplementation. New England Journal of Medicine 330(23): 1687-1688, 1994

Modelling the potential impact of population-wide periconceptional folate/multivitamin supplementation on multiple births. Bjog 108(9): 937-942, 2001

Multivitamin supplementation and multiple births. American Journal Of Medical Genetics. 71(1): 93-96, 1997

Periconceptional folic acid supplementation in relation to multiple births. American Journal of Epidemiology 143(11 SUPPL ): S1, 1996

No association between periconceptional multivitamin supplementation and risk of multiple congenital abnormalities: a population-based case-control study. American Journal of Medical Genetics. Part A 140(22): 2469-2477, 2006

Association of periconceptional multivitamin use and risk of preterm or small-for-gestational-age births. American Journal of Epidemiology 166(3): 296-303, 2007

Periconceptional multivitamin use and risk of preterm or small-for-gestational-age births in the Danish National Birth Cohort. American Journal of Clinical Nutrition 94(3): 906-912, 2011

Periconceptional multivitamin supplementation and multimalformed offspring. Obstetrics and Gynecology New York 102(6): 1255-1261, 2003

Periconceptional folic acid containing multivitamin supplementation. European Journal Of Obstetrics & Gynecology & Reproductive Biology. 78(2): 151-161, E, 1998

Periconceptional multivitamin supplementation and nonneural midline defects. American Journal of Medical Genetics 46(5): 611-611, 1993

Prevention of congenital abnormalities by periconceptional multivitamin supplementation. Bmj 306(6893): 1645-1648, 1993

Postnatal somatic and mental development after periconceptional multivitamin supplementation. Archives of Disease in Childhood 70(3): 229-233, 1994

Birth prevalence of congenital anomalies after periconceptional multivitamin supplementation. Teratology 40(3): 282, 1989