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Human CD30+ cells are induced by Mycobacterium tuberculosis and present in tuberculosis lesions

Human CD30+ cells are induced by Mycobacterium tuberculosis and present in tuberculosis lesions

International Immunology 9(5): 713-720

ISSN/ISBN: 0953-8178

PMID: 9184916

DOI: 10.1093/intimm/9.5.713

CD30 is a member of the tumor necrosis factor/nerve growth factor receptor family and evidence has been presented that activated CD4+ CD45Ro+ T cells of T-h2 type selectively express CD30. Mycobacterium tuberculosis, a facultative intracellular bacterium capable of replicating in resting macrophages, is a potent inducer of IFN-gamma secretion by T-h1 cells. We find increased CD30 expression by M. tuberculosis-stimulated alpha-beta and gamma-delta T cells, and elevated numbers of CD30+ alpha-beta T cells in tuberculosis pleuritis and affected lung tissue. Furthermore, surface CD30 was associated with intracytoplasmic IFN-gamma expression and IFN-gamma production by M. tuberculosis-stimulated alpha-beta and gamma-delta T cells. Thus, our results indicate that M. tuberculosis is a potent inducer of CD30 expression in T-h1 cells and argue against exclusive correlation of CD30 expression with T-h2 cell responses.

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Accession: 008785589

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