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Human parainfluenza virus type 1 evolution combines cocirculation of strains and development of geographically restricted lineages



Human parainfluenza virus type 1 evolution combines cocirculation of strains and development of geographically restricted lineages



Journal of Infectious Diseases 169(2): 248-252



The hemagglutinin neuraminidase (HN) glycoprotein of human parainfluenza virus type 1 (HPIV-1) mediates attachment to the host cell and is the target of protective antibody. Since the efficacy of a potential vaccine depends on antigenic constancy, the antigenic and genetic stability of the HPIV-1 HN glycoprotein was examined for 13 isolates obtained between 1981 and 1989. Antigenic analysis with a panel of 11 monoclonal antibodies demonstrated a single change among 3 isolates from 1989 that distinguished them from all other isolates. The HN genes from all 13 isolates and 13 previously published HN gene sequences shared > 95% homology. Evolutionary analysis demonstrated cocirculation of strains, without a dominant lineage. The 1989 isolates and the previously proposed subtype A isolates occupied distinct evolutionary branches, indicating geographically limited evolution. The slow rate of evolution and HN homogeneity may allow development of a single vaccine formulation for the prevention of disease.

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Accession: 008785933

Download citation: RISBibTeXText

PMID: 7508966

DOI: 10.1093/infdis/169.2.248


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