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IL-1 and tumor necrosis factor-alpha each up-regulate both the expression of IFN-gamma receptors and enhance IFN-gamma-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1)

Krakauer, T.; Oppenheim, J.J.

Journal of Immunology 150(4): 1205-1211

1993

ISSN/ISBN: 0022-1767
PMID: 8432976
Accession: 008799520
Stimulation of human blood monocytes (adherent mononuclear cells) and the monocytic cell line, THP-1, by IL-1 or TNF-alpha leads to the up-regulation of IFN-gamma receptors. Scatchard analysis using 125I-IFN-gamma revealed a twofold increase in the number of IFN-gamma receptors on THP-1 cells without an alteration in the affinity of the receptor.

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Related References

Krakauer, T.; Oppenheim, J.J. 1993: IL-1 and tumor necrosis factor-a each up-regulate both the expression of IFN-c receptors and enhance IFN-c-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1) Journal of Immunology 150: 05-11
Krakauer, T.; Oppenheim, J.J. 1993: IL-1 and tumor necrosis factor-α each up-regulate both the expression of IFN-γ receptors and enhance IFN-γ-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1) The Journal of Immunology (1950) 150(4): 1205-1211
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