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Identification of thiocyanate as the principal metabolite of oxamyl in lactating goat


, : Identification of thiocyanate as the principal metabolite of oxamyl in lactating goat. Journal Of Agricultural & Food Chemistry. 45(3): 962-966

The metabolic fate of (1-14C)oxamyl in a lactating goat was investigated. The test animal was administered five consecutive daily doses orally at 31 ppm oxamyl dietary burden. Most of the radioactivity was eliminated via urine (45.3%) and feces (7.2%). (14C)Oxamyl equivalents in edible tissues (liver, kidney, muscle, and fat) and in milk accounted for 6.7 and 10.2% of the dose, respectively. A small percentage (1.9%) of the dose was exhaled as volatile metabolites (primarily 14CO-2). No oxamyl nor any closely related metabolites were detected in tissues, milk, or urine. Extensive degradation/metabolism of (1-14C)oxamyl was observed. Radioactive thiocyanate was the major metabolite identified in the milk as well as in the methanol/water extracts for all tissue samples. Oxamyl-derived residues in the urine have been identified as thiocyanate, N-methyloxamic acid, oxamide, and N-methyloxamide.

Accession: 008811528

DOI: 10.1021/jf960548i

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