+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immune response characteristics in women with chlamydial genital tract infection

Immune response characteristics in women with chlamydial genital tract infection

Gynecologic and Obstetric Investigation 39(1): 54-59

Immune responses in women with chlamydial genital tract infection who achieved a bacteriologic cure were prospectively compared to those women who had an incomplete clinical response. Local anti-chlamydia IgA antibody responses were significantly diminished in the outpatient treatment group who had an incomplete response, while circulating IgG responses did not differ significantly between groups. This is in contrast to both specific and non-specific lymphoproliferative responses which were similar between uninfected controls and women with a chlamydial genital tract infection, regardless of treatment outcome. Thus, the kinetics of successful outpatient treatment of chlamydial genital tract infections may have an immunologic component which can be measured at the time of initial evaluation, and may be predictive of the clinical response to adjunctive antibiotics.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008816096

Download citation: RISBibTeXText

PMID: 7890255

DOI: 10.1159/000292377

Related references

Subclinical chlamydial infection of the female mouse genital tract generates a potent protective immune response: implications for development of live attenuated chlamydial vaccine strains. Infection and Immunity 68(1): 192-196, 2000

Subclinical Chlamydial Infection of the Female Mouse Genital Tract Generates a Potent Protective Immune Response: Implications for Development of Live Attenuated Chlamydial Vaccine Strains. Infection and Immunity 68(1): 192-196, 2000

Cell-mediated immune responses in the genital tract and genital-associated lymph nodes to murine chlamydial genital infection. Abstracts of the General Meeting of the American Society for Microbiology 95: 277, 1995

Does detection of chlamydial antibodies by microimmunofluorescence help in managing chlamydial lower genital tract infection in women?. Genitourinary Medicine 61(3): 172-174, 1985

Chlamydial serologic characteristics among intrauterine contraceptive device users: Does copper inhibit chlamydial infection in the female genital tract?. American Journal of Obstetrics and Gynecology 171(3): 691-693, 1994

Protective or pathogenic immune response to genital chlamydial infection in women--a possible role of cytokine secretion profile of cervical mucosal cells. Clinical Immunology 130(3): 347-354, 2009

Characterization of lymphocyte response in the female genital tract during ascending Chlamydial genital infection in the guinea pig model. Infection and Immunity 68(9): 5293-5298, 2000

Chlamydial variants differ in ability to ascend the genital tract in the guinea pig model of chlamydial genital infection. Infection and Immunity 83(8): 3176-3183, 2015

Chlamydial Infection Of The Lower Genital Tract Of Women. British Medical Bulletin 39(2): 138-144, 1983

Chlamydial infection of the lower genital tract of women. British Medical Bulletin 39(2): 138-144, 1983

Clinical consequences of immune response to CT upper genital tract infection in women. Infectious Diseases in Obstetrics and Gynecology 4(3): 171-175, 1996

Silent upper genital tract chlamydial infection and disease in women. International Journal of Std and Aids 8(5): 329-331, 1997

Protective efficacy of a parenterally administered MOMP-derived synthetic oligopeptide vaccine in a murine model of Chlamydia trachomatis genital tract infection: Serum neutralizing IgG antibodies do not protect against chlamydial genital tract infection. Vaccine 13(11): 1023-1032, 1995

Is it time to switch to doxycycline from azithromycin for treating genital chlamydial infections in women? Modelling the impact of autoinoculation from the gastrointestinal tract to the genital tract. Bmc Infectious Diseases 15: 200, 2015

Chlamydial genital tract infections. Experimental infection of the primate genital tract with Chlamydia trachomatis. American Journal of Pathology 106(1): 132-135, 1982