+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunologic parameters 2 years after high-titer measles immunization in Peruvian children

Immunologic parameters 2 years after high-titer measles immunization in Peruvian children

Journal of Infectious Diseases 168(5): 1097-1104

Immunization with high-titer measles vaccines has been associated with excess mortality in children 2-4 years after vaccination. In this study, immunologic parameters in 64 Peruvian children who had been immunized an average of 27 months earlier with high-titer vaccines were compared with parameters in 76 recipients of low-titer vaccines. Delayed-type hypersensitivity, lymphocyte phenotype distributions by flow cytometry, and lymphoproliferation after phytohemagglutinin (PHA) stimulation were assessed. High-titer recipients had smaller indurations to tetanus, diphtheria, and Proteus (P < .05) antigens, decreased PHA stimulation (P = .04), and a lower percentage of CD4+ lymphocytes (P = .04) than low-titer recipients. After adjustment for sex, concurrent illnesses, and other variables in regression analyses, high-titer recipients had a lower percentage of CD4+ lymphocytes (P = .025) and decreased lymphocyte proliferation to PHA (P = .058). These results may provide a clue to the pathogenesis of delayed excess mortality after high-titer measles vaccination in some developing countries.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008822713

Download citation: RISBibTeXText

PMID: 8228341

DOI: 10.2307/30113619

Related references

Immunologic Parameters 2 Years after High-Titer Measles Immunization in Peruvian Childre. Journal of Infectious Diseases 168(5): 1097-1104, 1993

Poor serologic responses five to seven years after immunization with high and standard titer measles vaccines. Pediatric Infectious Disease Journal 18(1): 53-57, 1999

Possible mechanisms of immunologic changes after high-titer measles vaccination. Ginsberg, H S, Brown, F, Chanok, R M, Lerner, R A Vaccines (Cold Spring Harbor); Modern approaches to new vaccines including prevention of AIDS: 329-335, 1993

Comparison of high titer Edmonston-Zagreb, Biken-CAM and Schwarz measles vaccines in Peruvian infants. Pediatric Infectious Disease Journal 11(10): 822-827, 1992

Measles humoral and cell-mediated immunity in children aged 5-10 years after primary measles immunization administered at 6 or 9 months of age. Journal of Infectious Diseases 207(4): 574-582, 2013

Reactogenic properties and immunologic effectiveness of several series of live Leningrad-16 measles vaccine used for mass immunization of children. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1976(1): 144-145, 1976

Divergent mortality for male and female recipients of low-titer and high-titer measles vaccines in rural Senegal. American Journal of Epidemiology 138(9): 746-755, 1993

Functional antibody responses in children receiving standard or high-titer measles vaccines. Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy 36: 174, 1996

Prevalence of hepatitis B infection in children under 5 years old on indigenous communities of the Peruvian Amazonia after immunization interventions. Revista Peruana de Medicina Experimental y Salud Publica 31(2): 204-210, 2014

Immunologic studies of specific mucosal and systemic immune responses in Mexican school children after booster aerosol or subcutaneous immunization with measles vaccine. Vaccine 22(9-10): 1214-1220, 2004

Interventions for the control of diarrheal diseases in children under five years of age 2. immunization against measles. Boletin de la Oficina Sanitaria Panamericana 99(3): 217-234, 1985

Randomized Trials Comparing Inactivated Vaccine After Medium- or High-titer Measles Vaccine With Standard Titer Measles Vaccine After Inactivated Vaccine: A Meta-analysis. Pediatric Infectious Disease Journal 35(11): 1232-1241, 2016

Immunogenicity of high-titer Edmonston-Zagreb measles vaccine in human immunodeficiency virus-infected children in Kinshasa, Zaire. Journal of Infectious Diseases 167(6): 1418-1421, 1993

Measles, mumps, and rubella antibodies in children 5-6 years after immunization: Effect of vaccine type and age at vaccination. Vaccine 13(16): 1611-1616, 1995

Relationship between occurrence of Guillain-Barre syndrome and mass campaign of measles and rubella immunization in Iranian 5-14 years old children. Vaccine 26(39): 5058-5061, 2008