EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Immunological responses to respiratory syncytial virus infection in infancy


Immunological responses to respiratory syncytial virus infection in infancy



Archives of Disease in Childhood 76(3): 210-214



ISSN/ISBN: 0003-9888

PMID: 9135260

DOI: 10.1136/adc.76.3.210

Objectives: To determine whether there is evidence of immunological responses in infants with respiratory syncytial virus (RSV) bronchiolitis by measuring inflammatory mediators in peripheral blood and, if found, whether these related to the severity of illness. Patients and methods: Blood was taken from 94 children with RSV infection during the acute episode and 10 or more days later when the child was well. Control serum samples were obtained from well children of similar ages. Serum samples were assayed for mediators of lymphocyte activity (interleukin-4 (IL-4), soluble interleukin-2 receptor (sCD25), soluble intercellular adhesion molecule-1 (sICAM-1), eosinophil activity (eosinophil cationic protein) and neutrophil activity (myeloperoxidase). Symptoms were assessed as very mild (coryza only), mild (symptoms of lower respiratory tract infection), moderate (requiring nasogastric or intravenous fluids), and severe (requiring oxygen or ventilation). Results: IL-4 concentrations were at the lower limits of detection of the assay. The concentrations of sCD-25 were greater in samples from patients with acute illness than from convalescent patients and both were greater than in control samples. sICAM-1 concentrations were similar in samples from patients with acute illness and convalescent patients, but both were greater than in samples from controls. Eosinophil cationic protein concentrations were lower in samples from patients with acute illness than in those from convalescent patients; there was no difference between samples from convalescent and control patients. Myeloperoxidase concentrations were similar in all samples. There was no correlation between the severity of infection and the concentrations of any inflammatory mediators. Conclusions: There is evidence of an inflammatory response in the peripheral blood of infants with acute bronchiolitis which may affect lymphocytes and eosinophils, but an association between this response and the severity of illness was not shown here.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008823427

Download citation: RISBibTeXText

Related references

Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responses. Allergy and Asthma Proceedings 23(6): 399-405, 2002

Characterization of a bovine model for studying the immunological responses to respiratory syncytial virus infection. FASEB Journal 8(4-5): A490, 1994

Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity. Pediatric Pulmonology 33(6): 458-465, 2002

Research progress of respiratory syncytial virus (RSV) infection and respiratory diseases in infancy. Sheng Li Xue Bao: 73(6): 1043-1053, 2021

Effects of Respiratory Syncytial Virus Infection in Infancy on Asthma and Respiratory Allergy in 6-Year-Old Children. Southern Medical Journal 111(11): 698-702, 2018

Upper respiratory tract bacterial-immune interactions during respiratory syncytial virus infection in infancy. Journal of Allergy and Clinical Immunology 149(3): 966-976, 2022

Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract Infection With Human Rhinovirus and Respiratory Syncytial Virus in Infancy. Journal of Infectious Diseases 214(12): 1924-1928, 2016

Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up. Allergy 64(9): 1359-1365, 2009

Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge. Human Vaccines and Immunotherapeutics 16(3): 664-672, 2020

Correlates of Protection Against Respiratory Syncytial Virus Infection in Infancy. Clinical Reviews in Allergy and Immunology 2022, 2022

Asthma and respiratory syncytial virus infection in infancy: is there a link?. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 28(8): 927-935, 1998

Maternal antibody and respiratory syncytial virus infection in infancy. Journal of Medical Virology 7(4): 263-271, 1981

Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy. European Respiratory Journal 20(2): 376-382, 2002

Respiratory syncytial virus infection in children hospitalized for wheezing: virus-specific studies from infancy to preschool years. Acta Paediatrica 94(2): 159-165, 2005

Serum levels of LIF in relation to respiratory syncytial virus infection in infancy. Allergy 56(Suppl 68): 139, 2001