Home
  >  
Section 9
  >  
Chapter 8,831

Importance of the two interferon-stimulated response element (ISRE) sequences in the regulation of the human indoleamine 2,3-dioxygenase gene

Konan, K.V.; Taylor, M.W.

Journal of Biological Chemistry 271(32): 19140-19145

1996

ISSN/ISBN: 0021-9258
PMID: 8702590
DOI: 10.1074/jbc.271.32.19140
Accession: 008830209
Indoleamine 2,3-dioxygenase (INDO) is the rate-limiting enzyme in the catabolism of the essential amino acid L-tryptophan. It is induced strongly in many cell lines following interferon-gamma treatment. We report the cloning and characterization of the full-length human INDO promoter. This promoter is 1,245 base pairs long and includes two interferon-stimulated response elements (ISRE) separated by an approximately 1-kilobase sequence.

PDF emailed within 0-6 h: $19.90




Related References

Dai, W.; Gupta, S.L. 1990: Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-c. Upstream control region discriminates between interferon-c and interferon-a The Journal of Biological Chemistry 265: 871-7
Wei, D.A.I.; Gupta, S.L. 1990: Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-γ : upstream control region dicriminates between interferon-γ and interferon-α The Journal of Biological Chemistry 265(32): 19871-19877
Dai, W.; Gupta, S.L. 1990: Differential regulation of human indoleamine 2 3 dioxygenase gene expression by interferon gamma and interferon alpha Journal of Interferon Research 10(Suppl 1): S43
Hassanain, H.H.; Sook Young, C.H.O.N.; Gupta, S.L. 1993: Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-γ and -α : analysis of the regulation region of the gene and identification of an interferon-γ-inducible DNA-binding factor The Journal of Biological Chemistry 268(7): 5077-5084
Dai, W.; Gupta, S.L. 1990: Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-gamma. Upstream control region discriminates between interferon-gamma and interferon-alpha Journal of Biological Chemistry 265(32): 19871-19877
Chon, S.Y.; Hassanain, H.H.; Gupta, S.L. 1996: Cooperative role of interferon regulatory factor 1 and p91 (Stat1) response elements in interferon-c-inducible expression of human indoleamine 2,3-dioxygenase gene The Journal of Biological Chemistry 271: 247-52
Chon, S.Y.; Hassanain, H.H.; Gupta, S.L. 1996: Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene Journal of Biological Chemistry 271(29): 17247-17252
Sheikh, S.Z.; Kobayashi, T.; Matsuoka, K.; Onyiah, J.C.; Plevy, S.E. 2011: Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter Journal of Biological Chemistry 286(2): 1174-1180
Ward, S.V.; Samuel, C.E. 2002: Regulation of the interferon-inducible PKR kinase gene: the KCS element is a constitutive promoter element that functions in concert with the interferon-stimulated response element Virology 296(1): 136-146
Matsuyama, T.; Grossman, A.; Mittrücker, H.W.; Siderovski, D.P.; Kiefer, F.; Kawakami, T.; Richardson, C.D.; Taniguchi, T.; Yoshinaga, S.K.; Mak, T.W. 1995: Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE) Nucleic Acids Research 23(12): 2127-2136
Hassanain, H.H.; Chon, S.Y.; Gupta, S.L. 1993: Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-c and -a. Analysis of the regulatory region of the gene and identification of an interferon-c-inducible DNA-binding factor The Journal of Biological Chemistry 268: 77-84
Behr, M.; Schieferdecker, K.; Bühr, P.; Büter, M.; Petsophonsakul, W.; Sirirungsi, W.; Redmann-Müller, I.; Müller, U.; Prempracha, N.; Jungwirth, C. 2001: Interferon-stimulated response element (ISRE)-binding protein complex DRAF1 is activated in Sindbis virus (HR)-infected cells Journal of Interferon and Cytokine Research: the Official Journal of the International Society for Interferon and Cytokine Research 21(11): 981-990
Hassanain, H.H.; Chon, S.Y.; Gupta, S.L. 1993: Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor Journal of Biological Chemistry 268(7): 5077-5084
Dai, W.; Gupta, S.L. 1991: Interferon gamma and interferon alpha differentially regulate the expression of human indoleamine 2 3 dioxygenase gene Proceedings of the American Association for Cancer Research Annual Meeting 32: 295
Lucas, D.M.; Mcdowell, M.A.; Nicolet, C.; Paulnock, D.M. 1995: Interferon stimulated response element-dependent gene regulation by interferon-gamma in macrophages FASEB Journal 9(3): A509