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Importance of the two interferon-stimulated response element (ISRE) sequences in the regulation of the human indoleamine 2,3-dioxygenase gene

Konan, K.V.; Taylor, M.W.

Journal of Biological Chemistry 271(32): 19140-19145

1996


ISSN/ISBN: 0021-9258
PMID: 8702590
DOI: 10.1074/jbc.271.32.19140
Accession: 008830209

Indoleamine 2,3-dioxygenase (INDO) is the rate-limiting enzyme in the catabolism of the essential amino acid L-tryptophan. It is induced strongly in many cell lines following interferon-gamma treatment. We report the cloning and characterization of the full-length human INDO promoter. This promoter is 1,245 base pairs long and includes two interferon-stimulated response elements (ISRE) separated by an approximately 1-kilobase sequence.

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