In vitro effect of alveolar macrophages of dust-exposed rabbit on lung fibroblasts (V79)

Xia, Z.; Ke, F.

Hua Xi Yi Ke Da Xue Xue Bao 24(1): 87-91


ISSN/ISBN: 0257-7712
PMID: 8340100
Accession: 008837201

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This is a study of the interactions between rabbit alveolar macrophages (AM) and Chinese hamster lung fibroblasts (V-79) mediated by Xinkang chrysotile asbestos, UICC Canadian chrysotile B asbestos, quartz and pure titanium dioxide on (1) fibroblast proliferation, (2) collagen synthesis and (3) morphological changes. In comparison with the control, the results of 3H-TdR incorporation, histochemical staining and quantitative microscopic observation of V-79 cell suggested that the supernatants of AM treated by the four kinds of dust could stimulate the proliferation and collagen accumulation of V-79 cell group. As to the degree of fibrosis resulting from the dust, Xinkang asbestos was noted to be similar to quartz but stronger than UICC asbestos; the effect of TiO-2 was the weakest.