Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization

Blanco, J.; Egozcue, J.; Vidal, F.

Human Reproduction 11(4): 722-726

1996


ISSN/ISBN: 0268-1161
PMID: 8671315
DOI: 10.1093/oxfordjournals.humrep.a019241
Accession: 008845473

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Abstract
We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6 (0.14%). No differences were found among the individuals analysed.