+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Incidence of optic neuritis in Stockholm, Sweden 1990-1995: I. Age, sex, birth and ethnic-group related patterns



Incidence of optic neuritis in Stockholm, Sweden 1990-1995: I. Age, sex, birth and ethnic-group related patterns



Journal of the Neurological Sciences 159(1): 107-114



We studied the incidence of monosymptomatic optic neuritis (MON) in Stockholm county, Sweden and its variation with person-related factors. Patients with suspected or diagnosed MON between January 1, 1990 and December 31, 1995 were referred from ophthalmologists and neurologists to a research registry. The diagnosis was based on accepted clinical criteria only, and verified by an ophthalmologist who examined all the patients. Data were collected by interview using a structured questionnaire. The crude mean annual incidence, based on 147 patients, 118 females and 29 males, diagnosed with MON, was 1.46 per 100,000 person-years, 2.28 for females and 0.59 for males. The corresponding age-adjusted incidences were 1.40, 2.28 and 0.53. The age-specific incidence curve for both sexes suggested a bimodal distribution with peaks at 30-34 years and 45-49 years. The smoothed cumulative incidences in 1 year birth cohorts showed a notchy profile, related to bimodality. The incidence among residents born out of the Nordic countries was low, 0.28 per 100,000. Patients with onset of MON before 40 years of age had a significantly higher frequency of mononuclear pleocytosis in cerebrospinal fluid and shorter duration to conversion to multiple sclerosis. In summary, MON occurred in Stockholm at a relatively low frequency, particularly among males. The presence of particular birth date and birth place related patterns might be etiologically relevant.

(PDF emailed within 0-6 h: $19.90)

Accession: 008845835

Download citation: RISBibTeXText

PMID: 9700712

DOI: 10.1016/s0022-510x(98)00141-5


Related references

Incidence of optic neuritis in Stockholm, Sweden, 1990-1995: II. Time and space patterns. Archives of Neurology 56(8): 975-980, 1999

Optic neuritis in Stockholm, Sweden, 1900-1995 Paraclinical profile and its prognosis for multiple sclerosis. Neurology 48(3 SUPPL 2): A423-A424, 1997

Incidence of acute idiopathic optic neuritis and its therapy in Japan. Optic Neuritis Treatment Trial Multicenter Cooperative Research Group (ONMRG). Nippon Ganka Gakkai Zasshi 99(1): 93-97, 1995

The SKILL Card test in optic neuritis: experience of the Optic Neuritis Treatment Trial. Smith-Kettlewell Institute Low Luminance. Optic Neuritis Study Group. Journal of Neuro-Ophthalmology 21(2): 124-131, 2001

Baseline visual field profile of optic neuritis. The experience of the optic neuritis treatment trial. Optic Neuritis Study Group. Archives of Ophthalmology 111(2): 231-234, 1993

Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group. Archives of Ophthalmology 115(12): 1545-1552, 1997

The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. Archives of Ophthalmology 109(12): 1673-1678, 1991

Meeting of the Swedish Ophthalmological Society, Norrkoping, Sweden, August 31-September 2, 1995, Stockholm, Sweden, November 29-December 1, 1995. Acta Ophthalmologica Scandinavica 74(5): 513-517, 1996

The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group. New England Journal of Medicine 329(24): 1764-1769, 1993

Visual field reading center optic neuritis treatment trial the optic neuritis study group. Investigative Ophthalmology & Visual Science 31(4 ABSTR ISSUE): 609, 1990

Brain magnetic resonance imaging in acute optic neuritis. Experience of the Optic Neuritis Study Group. Archives of Neurology 50(8): 841-846, 1993

A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. New England Journal of Medicine 326(9): 581-588, 1992

The Optic Neuritis Treatment Trial. Putting the results in perspective. The Optic Neuritis Study Group. Journal of Neuro-Ophthalmology 15(3): 131-135, 1995

The optic neuritis treatment trial. Implications for clinical practice. Optic Neuritis Study Group. Archives of Ophthalmology 110(3): 331-332, 1992