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Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus



Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus



European Journal of Endocrinology 136(2): 173-179



Objective: To explore a possible association between serum concentration of leptin, insulin sensitivity and non-insulin-dependent diabetes mellitus (NIDDM). Design: Forty first-degree relatives of NIDDM patients and 3 5 control subjects matched for age, gender and body mass index underwent a hyperinsulinemic (insulin infusion rate 0.6 mU/kg per min) euglycemic clamp combined with indirect calorimetry. Serum leptin was measured in fasting blood samples obtained before the clamp. Results: All subjects had a normal oral glucose tolerance test. Insulin-stimulated glucose uptake (M) was decreased in the relatives compared with the control subjects (4.58 +- 0.27 versus 6.06 +- 0.25 mg/kg per min, P lt 0.001). Conversely, serum leptin was increased in the relatives (9.6 cntdot / div 1.1 versus 6.1 cntdot / div 1.2 ng/ml (geometric mean cntdot / div antilog S.E.M.), P lt 0.05). A positive correlation was observed between circulating levels of leptin and percentage body fat (P lt 0.001) and inverse correlations were found between leptin, M (P lt 0.01), maximal aerobic capacity (VO-2 max) P lt 0.01), a energy expenditure (P ltoreq 0.01) in both groups. In multiple linear regression analysis, percentage body fat, gender and M significantly determined the level of leptin (r-2 = 0.71, P lt 0.001) whereas family history of NIDDM and VO-2 max did not. Conclusion: Serum leptin is increased in insulin-resistant offspring of NIDDM patients. The association between leptin, anthropometric measures and insulin sensitivity is, however, comparable with that of a control group. The increased concentrations of serum leptin in the relatives appear to be associated with the insulin resistance, but not with a family history of NIDDM.

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Accession: 008848657

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PMID: 9116912

DOI: 10.1530/eje.0.1360173


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