Induction of c-Fos-like protein in the lateral habenular nucleus by persistent noxious peripheral stimulation

Nagao, M.; Kamo, H.; Akiguchi, I.; Kimura, J.

Neuroscience Letters 151(1): 37-40


ISSN/ISBN: 0304-3940
PMID: 8469434
DOI: 10.1016/0304-3940(93)90039-n
Accession: 008857065

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Persistent noxious peripheral stimulation by formalin injection into the unilateral hindpad of anaesthetized rats induced c-Fos-like protein immunoreactivity (c-Fos-LI) in neurons within the lateral habenular nucleus (LHb) bilaterally. Formalin injection after the transection of spinal cords also induced c-Fos-LI in many neurons within the LHb, though the number of labeled cells changed depending on the post-transection period. These results suggest that the LHb modulates nociceptive information, but that it receives nociceptive information via extraspinal pathways as well as intraspinal ascending noxious pathways.