Section 9
Chapter 8,876

Inhibition of ADP-induced platelet responses by covalent modification of aggregin, a putative ADP receptor, by 8- (4-bromo-2,3-dioxobutylthio) ADP

Puri, R.N.; Kumar, A.; Chen, H.; Colman, R.F.; Colman, R.W.

Journal of Biological Chemistry 270(41): 24482-24488


ISSN/ISBN: 0021-9258
PMID: 7592664
DOI: 10.1074/jbc.270.41.24482
Accession: 008875490

Download citation:  

ADP is an important platelet agonist which initiates platelet shape change, aggregation, exposure of fibrinogen receptors, and calcium mobilization. Because of the limitations of previously used affinity analogs and photolabeling studies as well as controversies surrounding the identity of an ADP receptor on platelets, we have used an affinity label capable of alkylating a putative exofacial receptor on platelets.

PDF emailed within 0-6 h: $19.90