Inhibitory effects of total saponins extracted from Panax ginseng, Panax quinquefolium and Panax notoginseng on platelet function and thrombosis in rats
Pan, X.X.; Yan, Q.S.; Liu, T.P.
Zhongguo Yaolixue Yu Dulixue Zazhi 7(2): 141-144
1993
Accession: 008883296
Actions of total saponins extracted from Panax ginseng(SPQ), Panax quinquefolium(SPQ) and Panax notoginseng (SPNG) were studied both in vitro and in vivo. Total saponins, when tested in vitro, inhibited collagen-induced rat platelet aggregation with an IC-50 of 0.583, 1.012 and 0.815 g cntdot L-1, respectively. Percentages of inhibition of 5-HT release from rat platelet at a dose of 0.5 mg cntdot ml-1 of each saponin were found to be 20%, 4% and 16%, respectively. When the rats were given a dose of 35 mg cntdot kg-1 intravenously, their platelet cAMP concentrations were raised to a similar level in these three saponins. However, their in vivo actions were different. SPNG 80 mg cntdot kg-1 significantly inhibited thrombosis (Umetsu's method) 1.5-2 h after oral administration, whereas the same dose of SPG was ineffective. Rg-1 at a dose of 20 mg cntdot kg-1 ig could also inhibit thrombosis significantly, and inhibit the reduction of platelet counts and the increase of fibrin degradation product (FDP) caused by thrombus-induced disseminated intravascular coagulation, but the drug had no obvious effect on fibrinogen content and prothrombin time.