Section 9
Chapter 8,884

Inhibitory effects of total saponins extracted from Panax ginseng, Panax quinquefolium and Panax notoginseng on platelet function and thrombosis in rats

Pan, X.X.; Yan, Q.S.; Liu, T.P.

Zhongguo Yaolixue Yu Dulixue Zazhi 7(2): 141-144


Accession: 008883296

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Actions of total saponins extracted from Panax ginseng(SPQ), Panax quinquefolium(SPQ) and Panax notoginseng (SPNG) were studied both in vitro and in vivo. Total saponins, when tested in vitro, inhibited collagen-induced rat platelet aggregation with an IC-50 of 0.583, 1.012 and 0.815 g cntdot L-1, respectively. Percentages of inhibition of 5-HT release from rat platelet at a dose of 0.5 mg cntdot ml-1 of each saponin were found to be 20%, 4% and 16%, respectively. When the rats were given a dose of 35 mg cntdot kg-1 intravenously, their platelet cAMP concentrations were raised to a similar level in these three saponins. However, their in vivo actions were different. SPNG 80 mg cntdot kg-1 significantly inhibited thrombosis (Umetsu's method) 1.5-2 h after oral administration, whereas the same dose of SPG was ineffective. Rg-1 at a dose of 20 mg cntdot kg-1 ig could also inhibit thrombosis significantly, and inhibit the reduction of platelet counts and the increase of fibrin degradation product (FDP) caused by thrombus-induced disseminated intravascular coagulation, but the drug had no obvious effect on fibrinogen content and prothrombin time.

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