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Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: a minimal model analysis



Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: a minimal model analysis



Metabolism: Clinical and Experimental 43(6): 714-718



The aim of the present study was to estimate insulin secretion, insulin sensitivity (S-I), and glucose effectiveness (S-G) in non-obese Japanese subjects with impaired glucose tolerance (IGT). Ten IGT subjects (five men, five women) and 15 normal-tolerance subjects (seven men, eight women) without a family history of diabetes were studied. They underwent a modified frequently sampled intravenous glucose tolerance test (FSIGT); glucose (300 mg/kg body weight) was administered, and insulin (20 mU/kg over 5 minutes) was infused from 20 to 25 minutes after the administration of glucose, S-I and S-G were estimated by Bergman's minimal model method. No significant difference was observed in body mass index ((BMI) 22.1 +- 0.8 v 21.1 +- 0.5 kg/m-2), fasting plasma glucose (5.19 +- 0.18 v 5.07 +- 0.11 mmol/L), and insulin levels (50.7 +- 7.3 v 45.2 +- 4.5 pmol/L) of subjects with IGT and normal controls. The glucose disappearance rate (K-G) was significantly lower in subjects with IGT than in normal-tolerance subjects (1.57 +- 0.20 v 2.09 +- 0.15 %/min, P lt .05). Pancreatic insulin secretion expressed as the integrated area of plasma insulin above the basal level during the first 20 minutes was lower in IGT subjects (2,556 +- 572 pmol/L times min) than in normal-tolerance subjects (4,957 +- 800 pmol/L times min, P lt .05). S-I was not statistically different between the two groups (0.84 +- 0.13 times 10-4 v 1.14 +- 0.15 times 10-4 min-1 cntdot pmol/L-1). However, SG was significantly lower in subjects with IGT than in normal controls (0.013 +- 0.002 v 0.023 +- 0.002 min-1, P lt .01). The basal insulin effect (BIE) of IGT subjects was not significantly different from that of normal subjects (0.004 +- 0.0004 v 0.005 +- 0.001 times min-1),whereas glucose effectiveness at zero insulin (GEZI) was significantly lower in IGT subjects than in normal subjects (0.010 +- 0.002 v 0.018 +- 0.002 min-1, P lt .01). Thus, Japanese IGT subjects with normal S-I are characterized by mild impairments in pancreatic insulin secretion and decreased S-G and GEZI.

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Accession: 008887339

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PMID: 8201959

DOI: 10.1016/0026-0495(94)90119-8


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