+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Insulin-like growth factor I does not inhibit insulin secretion in adult human pancreatic islets in tissue culture



Insulin-like growth factor I does not inhibit insulin secretion in adult human pancreatic islets in tissue culture



European Journal of Endocrinology 133(2): 248-250



Insulin-like growth factor I (IGF-I) has been found to increase insulin sensitivity and suppress insulin secretion, thereby having a potential interest as a therapeutic agent for non-insulin-dependent diabetes mellitus (NIDDM). The aim of the present study was to investigate the direct actions of IGF-I (400 ng/ml) on human pancreatic islets, or on rat pancreatic islets, during a 48 h period in tissue culture. Insulin-like growth factor I did not affect medium insulin accumulation, DNA or insulin content or short-term glucose-induced insulin release of human islets. However, in rat islets the peptide induced a significant decrease in the insulin increase ratio in response to 16.7 mmol/l glucose. In conclusion, the present data suggest that IGF-I does not directly affect the function of human pancreatic beta-cells. If this in vitro data can be extrapolated to the in vivo situation, it suggests that the observed inhibitory effects of IGF-I on serum insulin levels may be secondary to peripheral effects of the peptide.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008887708

Download citation: RISBibTeXText

PMID: 7655651

DOI: 10.1530/eje.0.1330248


Related references

No effect of insulin like growth factor on insulin secretion from isolated pancreatic islets of the rat. Hormone Research 24(2-3): 199, 1986

Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 50(2): 380-389, 2007

Hypophysis and function of pancreatic islets. II. The effect of substitution with growth hormone and corticotrophin on insulin secretion and biosynthesis of proinsulin and insulin in isolated pancreatic islets of hypophysectomized rats. Diabetologia 9(2): 140-144, 1973

Stimulatory effect of insulin-like growth factor-I on [3H]thymidine incorporation, DNA content and insulin biosynthesis and secretion of isolated pancreatic rat islets. Journal of Endocrinology 117(1): 59-62, 1988

Growth hormone regulation of dna replication but not insulin production is mediated by insulin like growth factor i in isolated pancreatic islets from adult rats. Diabetologia 31(7): 547A, 1988

Growth hormone regulation of DNA replication, but not insulin production, is partly mediated by somatomedin-C/insulin-like growth factor I in isolated pancreatic islets from adult rats. Diabetologia 32(3): 191-197, 1989

Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets. Diabetologia 58(11): 2563-2572, 2015

Human growth hormone and insulin-like growth factor-I inhibit erythropoietin secretion from the kidneys of adult rats. Journal of Endocrinology 184(1): 199-207, 2005

Hypophysis and function of pancreatic islets. 3. Secretion and biosynthesis of insulin in isolated pancreatic islets of intact and hypophysectomized rats in the presence of growth hormone, corticotrophin and human chorionic somatotrophin in vitro. Hormone and Metabolic Research 5(1): 29-33, 1973

Maturation of stimulus recognition and insulin secretion during tissue culture of fetal pancreatic islets. Transactions of the American Clinical and Climatological Association 90: 86-93, 1979

Hypophysis and function of pancreatic islets part 3 secretion and biosynthesis of insulin in isolated pancreatic islets of intact and hypophysectomized rats in the presence of growth hormone cortico tropin and human chorionic somatotropin in vitro. Hormone & Metabolic Research: 29-33, 1973

Insulin secretion of cultured human adult and fetal pancreatic islets. Diabetologia 19(3): 277-278, 1980

Influence of the purification of human adult pancreatic islets on insulin secretion. Vojnosanitetski Pregled 67(2): 128-131, 2010

Hypophysis and function of pancreatic islets. I. The influence of hypophysectomy on insulin secretion and biosynthesis of proinsulin and insulin in isolated pancreatic islets of rats. Diabetologia 9(2): 135-139, 1973

Insulin secretion by fetal human pancreatic islets of Langerhans in prolonged organ culture. Diabetes 32(10): 915-920, 1983