EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Integrative immunophysiology in the intestinal mucosa


American Journal of Physiology 267(2 Pt 1): G151-G165
Integrative immunophysiology in the intestinal mucosa
Over the past ten years, it has become evident that intestinal epithelial functions such as ion secretion are a host defense response to the presence of antigens, microbes, and other noxious substances in the gut lumen. Such responses are mediated by the activation of immune cells in the mucosa causing. release of chemical mediators that act directly or indirectly on the epithelium. Frequently, immune cell products stimulate enteric nerves resulting in amplification. Thus immune cells and nerves form interactive units that can recognize various stimuli both specifically and nonspecifically and initiate mechanisms to eliminate offending material. Here, we review the current state of knowledge regarding immune regulation of epithelial physiology with particular emphasis on the ability of immune cells and their products (biogenic amines, cytokines, arachidonic acid metabolites, oxidants) to alter electrolyte transport. The mast cell will be highlighted in this scheme as this cell has been, and continues to be, the focus of extensive research efforts. However, recently it has become apparent that cells such as lymphocytes, macrophages, and polymorphonuclear leukocytes also play important roles in immunophysiology. The effect of immune cell activation on epithelial functions other than transport, such as permeability, proliferation, and antigen presentation, will be described where appropriate. Finally, we will present evidence that the enterocyte can express an "activated" phenotype and thus participate directly in mucosal immune responses.


Accession: 008889277

PMID: 8074215



Related references

Immunophysiology of the gut: a research frontier for integrative studies of the common mucosal immune system. American Journal of Physiology 265(4 Pt 1): G599-G610, 1993

The role of mast cells in intestinal immunophysiology. Advances in Experimental Medicine and Biology 371a: 287-292, 1995

The immunophysiology of mast cells in intestinal immunity and symbiosis. Blaser, M J [Editor], Smith, P D [Editor], Ravdin, J I [Editor], Greenberg, H/ B [Editor], Guerrant, R L [Editor] Infections of the gastrointestinal tract 227-236, 1995

On changes in the intestinal mucosa after direct action of various substances. III. Permeability change in the capillaries of the intestinal mucosa in the rat after enteral application of amines. Wiener Zeitschrift für Innere Medizin und Ihre Grenzgebiete 41: 138-142, 1960

On changes in the intestinal mucosa after direct action of various substances. II. Permeability change of the capillaries of the intestinal mucosa in the rat after enteral application of bile acids. Wiener Zeitschrift für Innere Medizin und Ihre Grenzgebiete 41: 134-137, 1960

Carbohydrases in the intestinal mucosa of the rabbit I The activities and their optimum pH of amylase, maltase, and sucrase of the rabbits intestinal mucosa. 1951

Morphometric analysis of intestinal mucosa : the measurement of volume compartments and cell volumes in human intestinal mucosa. Methods in Molecular Medicine 41: 125-145, 2000

Antioxidant and anti-inflammatory effects of selenium in oral buccal mucosa and small intestinal mucosa during intestinal ischemia-reperfusion injury. Journal of Inflammation 11(1): 36-36, 2014

Kinetics of oxygen utilization in intact intestinal mucosa and in intestinal mucosa two months after partial resection in the rat. Gastroenterology 44(6): 840-841, 1963

Studies on the phosphorylating action of the intestinal mucosa. I. On the optimal pH of the hydrolysis and synthesis of glycerophosphate by the intestinal mucosa. Acta Scholae Medicinalis Universitatis in Kioto 31(2): 116-120, 1953