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Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and amino(alpha)carboline



Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and amino(alpha)carboline



Carcinogenesis 17(10): 2259-2265



The heterocyclic amines produced during the cooking of meat, including amino(alpha)carboline (A-alpha-C) and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), are potent bacterial mutagens and are carcinogenic in rodents. PhIP is mutagenic in the small intestine, but its mutagenicity in the colon, where most human intestinal cancers arise, has not been reported, nor has the mutagenicity of A-alpha-C.

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