Section 9
Chapter 8,904

Intra-accumbens baclofen injection decreases the postural muscle activity in freely moving rats

Jelen, P.; Plaznik, A.; Kasicki, S.; Zagrodzka, J.

Neuroscience Research Communications 15(3): 149-156


ISSN/ISBN: 0893-6609
Accession: 008903753

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Baclofen, a GABA-B receptor agonist, was given intra-peritoneally or locally into the nucleus accumbens septi (NAS), and its influences on tonic postural soleus muscle activity, and on postural and stretch reflexes were studied electromyographically in freely moving rats. It was shown that after the drug the tonic muscle activity was significantly decreased, while the postural and stretch reflexes were not notably influenced. It is concluded that stimulation of GABA-B receptors within the NAS may be important for the control of tonic postural muscle activity. Thus, the supraspinal motor centers may significantly contribute to the action of muscle relaxant drugs.

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