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Invasive aspergillosis in liver transplant recipients: association with candidemia and consumption coagulopathy and failure of prophylaxis with low-dose amphotericin B


, : Invasive aspergillosis in liver transplant recipients: association with candidemia and consumption coagulopathy and failure of prophylaxis with low-dose amphotericin B. Clinical Infectious Diseases 17(5): 906-908

Invasive aspergillosis developed in three (5%) of 55 adult liver transplant recipients at our institution. All three of our patients had concomitant candidemia and consumption coagulopathy, and invasive aspergillosis developed while they were receiving therapy with intravenous amphotericin B (0.5 mg/(kg cntdot d)). The simultaneous occurrence of candidemia and invasive aspergillosis in liver transplant recipients may reflect a common defect in the host-defense mechanism against Candida and Aspergillus organisms (i.e., impaired phagocytic and mononuclear macrophage function) and liver disease per se. These three cases suggest that such low-dose intravenous amphotericin B will likely be ineffective if used as antifungal prophylaxis for invasive aspergillosis.

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Accession: 008911612

PMID: 8286639

DOI: 10.2307/4457462

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Related references

Singh, N.; Mieles, L.; Yu, V.L.; Gayowski, T., 1993: Invasive aspergillosis in liver transplant recipients Association with candidemia and consumption coagulopathy and failure of prophylaxis with low-dose intravenous amphotericin B. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 33(0): 342

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