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Involvement of aminopeptidase N (CD13) in infection of human neural cells by human coronavirus 229E



Involvement of aminopeptidase N (CD13) in infection of human neural cells by human coronavirus 229E



Journal of Virology 72(8): 6511-6519



Attachment to a cell surface receptor can be a major determinant of virus tropism. Previous studies have shown that human respiratory coronavirus HCV-229E uses human aminopeptidase N (hAPN (CD13)) as its cellular receptor for infection of lung fibroblasts. Although human coronaviruses are recognized respiratory pathogens, occasional reports have suggested their possible neurotropism.

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Accession: 008915074

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PMID: 9658094


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