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Iron induced oxidative stress and mitochondrial dysfunction: Relevance to Parkinson's disease



Iron induced oxidative stress and mitochondrial dysfunction: Relevance to Parkinson's disease



Brain Research 627(2): 349-353



Inactivation of the mitochondrial respiratory chain in response to iron-induced oxidative stress has been studied in cultured cells. Iron loading resulted in malondialdehyde production, decreased levels of glutathione and reduced specific activities of both complexes I and IV of the respiratory chain. These results are discussed with respect to idiopathic Parkinson's disease, which is associated with increased iron levels and a specific decrease in complex I activity in the substantia nigra.

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Accession: 008918364

Download citation: RISBibTeXText

PMID: 8298979

DOI: 10.1016/0006-8993(93)90341-j


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