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Is low magnesium concentration a risk factor for coronary heart disease? The atherosclerosis risk in communities (ARIC) study

Is low magnesium concentration a risk factor for coronary heart disease? The atherosclerosis risk in communities (ARIC) study

American Heart Journal 136(3): 480-490

Background: Hypomagnesemia has been hypothesized to play a role in coronary heart disease (CHD), but few prospective epidemiologic studies have been conducted. Methods and Results: We examined the relation of serum and dietary magnesium with CHD incidence in a sample of middle-aged adults (n = 13,922 free of baseline CHD) from 4 US communities. Over 4 to 7 years of follow-up, 223 men and 96 women had CHD develop. After adjustment for sociodemographic characteristics, waist/hip ratio, smoking, alcohol consumption, sports participation, use of diuretics, fibrinogen, total and high-density lipoprotein cholesterol levels, triglyceride levels, and hormone replacement therapy, the relative risk of CHD across quartiles of serum magnesium was 1.00, 0.92, 0.48, and 0.44 (P for trend = 0.009) among women and 1.00, 1.32, 0.95, and 0.73 (P for trend = 0.07) among men. The adjusted relative risk of CH D for the highest versus the lowest quartile of dietary magnesium was 0.69 in men (95% confidence interval 0.45 to 1.05) and 1.32 in women (0.68 to 2.55). Conclusions: These findings suggest that low magnesium concentration may contribute to the pathogenesis of coronary atherosclerosis or acute thrombosis.

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Accession: 008920226

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PMID: 9736141

DOI: 10.1016/s0002-8703(98)70224-8

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