Isolated hepatocyte couplets and bile duct units--novel preparations for the in vitro study of bile secretory function

Boyer, J.L.

Cell Biology and Toxicology 13(4-5): 289-300


ISSN/ISBN: 0742-2091
PMID: 9298249
DOI: 10.1023/a:1007435408208
Accession: 008923064

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Studies of the mechanisms of bile formation have been facilitated by the development of in-vitro models that enable the transport functions of hepatocytes and bile duct epithelial cells to be analyzed in isolation. Isolated hepatocyte couplets represent a primary bile secretory unit that retain secretory polarity. Isolated bile duct units are intact polarized segments of interlobular bile duct segments. Both preparations can be maintained in short term culture, respond appropriately to choleretic agonists and facilitate a variety of functional applications.