+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Laboratory and clinical studies of cefprozil in pediatric field



Laboratory and clinical studies of cefprozil in pediatric field



Japanese Journal of Antibiotics 45(11): 1582-1591



Laboratory and clinical studies were done on cefprozil (CFPZ, BMY-28100). The results are summarized as follows. CFPZ was administered through the oral route to 2 children at a single dose of 7.5 mg/kg. After administration, peak serum levels of CFPZ obtained in the 2 cases were 6.71 micrograms/ml at 1 hour and 6.45 micrograms/ml at 2 hours, respectively and half-lives were 1.28 hours and 0.92 hour, respectively. The urinary excretion rates of CFPZ were 58.9% and 59.4%, respectively. Treatment with CFPZ was made in 37 cases of pediatric bacterial infections: 1 case of pharyngitis, 16 cases of tonsillitis, 16 cases of scarlet fever, 3 cases of impetigo, 1 case of UTI. Results obtained were excellent in 24 cases, good in 13 cases. No significant side effects due to the drug were observed, except 1 case of loose stool, 3 cases of eosinophilia, and 1 case each of elevated GOT and GPT.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008939540

Download citation: RISBibTeXText

PMID: 1494239


Related references

Laboratory and clinical studies on cefprozil in the field of pediatrics. Japanese Journal of Antibiotics 45(11): 1558-1570, 1992

Pharmacokinetic and clinical studies on cefprozil granules in the pediatric field. Japanese Journal of Antibiotics 45(12): 1700-1735, 1992

Clinical evaluation of cefprozil granules in pediatric field. Japanese Journal of Antibiotics 45(12): 1658-1662, 1992

Laboratory and clinical studies on cefprozil granules in pediatrics. Japanese Journal of Antibiotics 45(11): 1526-1536, 1992

Pharmacokinetic, bacteriological and clinical studies on cefprozil in pediatric patients. Japanese Journal of Antibiotics 45(11): 1571-1581, 1992

Clinical studies on cefprozil granules in pediatric skin soft tissues infections. Japanese Journal of Antibiotics 45(12): 1684-1699, 1992

Laboratory and clinical studies of PC-904 in pediatric field. Japanese Journal of Antibiotics 31(7): 359-362, 1978

Laboratory and clinical studies of cefodizime in pediatric field. Japanese Journal of Antibiotics 43(9): 1603-1613, 1990

Laboratory and clinical studies of flomoxef in the pediatric field. Japanese Journal of Antibiotics 40(8): 1426-1438, 1987

Laboratory and clinical studies on norfloxacin in the pediatric field. Japanese Journal of Antibiotics 43(5): 808-825, 1990

Laboratory and clinical studies on cefoxitin in pediatric field. Japanese Journal of Antibiotics 34(3): 287-304, 1981

Laboratory and clinical studies on aztreonam in the pediatric field. Japanese Journal of Antibiotics 38(11): 3343-3348, 1985

Laboratory and clinical studies of sultamicillin in pediatric field. Japanese Journal of Antibiotics 41(12): 1923-1939, 1988

Laboratory and clinical studies of cefoperazone in pediatric field. Japanese Journal of Antibiotics 33(9): 899-909, 1980

Laboratory and clinical studies of ceftriaxone in the pediatric field. Japanese Journal of Antibiotics 37(11): 2131-2140, 1984