+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig



Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig



Inflammation Research. 45(3): 123-126



We have investigated the role of bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in sensitized guinea pigs. We used a selective bradykinin B2 receptor antagonist, HOE140, which has been shown to prevent the airway effects induced by bradykinin. Lung resistance (R-L) was measured for 6 min after challenge with allergen. Extravasation of Evans blue dye into airway tissues was used as an index of the airway microvascular leakage. Aerosolized ovalbumin (5 mg/ml, 30 breaths) induced a significant increase in R-L and leakage of dye in the trachea, main bronchi and intrapulmonary airways in the ovalbumin-sensitized guinea pigs. HOE140 given by inhalation (200 mu-M, 60 breaths) had no effect on the airway microvascular leakage and bronchoconstriction induced by the allergen. I.v. HOE140 (200 nmol/kg) did not significantly inhibit these airway responses. We conclude that bradykinin-mediated mechanism may not play a significant role in airway microvascular leakage or bronchoconstriction induced by allergen.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008940382

Download citation: RISBibTeXText

PMID: 8689390

DOI: 10.1007/bf02265164


Related references

Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. European Journal Of Pharmacology. 231(1): 31-38, 1993

Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. European Journal of Pharmacology 213(3): 367-373, 1992

Lack of a role for bradykinin in inhaled sodium metabisulphite-induced airway microvascular leakage in guinea pigs. Inflammopharmacology. 4(4): 323-330, 1996

Bradykinin-induced airway microvascular leakage and bronchoconstriction are mediated via a bradykinin B2 receptor. American Review of Respiratory Disease 142(5): 1104-1107, 1990

Bradykinin-induced airway microvascular leakage and bronchoconstriction are mediated via a bradykinin B2 receptor. American Review of Respiratory Disease 144(1): 237-239, 1991

Role of thromoxane a2 in airflow obstruction and airway microvascular leakage induced by bradykinin in guinea pig. American Review of Respiratory Disease 145(4 Part 2): A612, 1992

Bradykinin induced airway narrowing and airway narrowing and airway microvascular leakage in guinea pig role of cholinergic nerves and of arachidonic acid metabolites. American Review of Respiratory Disease 145(4 Part 2): A612, 1992

Role of neutrophil elastase in allergen-induced airway microvascular leakage in sensitized guinea pigs. Arerugi 46(6): 496-501, 1997

Adrenomedullin inhibits ovalbumin-induced bronchoconstriction and airway microvascular leakage in guinea-pigs. European Respiratory Journal 14(5): 1076-1081, 1999

Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Prostaglandins Leukotrienes & Essential Fatty Acids. 52(6): 403-411, 1995

Pharmacological modulation of inhaled sodium metabisulphite-induced airway microvascular leakage and bronchoconstriction in the guinea-pig. British Journal Of Pharmacology. 107(2): 481-487, 1992

Effects of uroguanylin and guanylin against antigen-induced bronchoconstriction and airway microvascular leakage in sensitized guinea-pigs. Life Sciences. 62(20): 1833-1844, Il 10, 1998

Effect ofβ(in2)-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Inflammation Research 40(1-2): 50-56, 1993

Effects of tachykinin receptor antagonists on leukotriene C-4-induced bronchoconstriction and airway microvascular leakage in guinea pigs. Zhongguo Yaolixue Yu Dulixue Zazhi 11(1): 11-13, 1997

Formoterol and salbutamol inhibit bradykinin- and histamine-induced airway microvascular leakage in guinea-pig. British Journal of Pharmacology 105(4): 792-798, 1992