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Lactic dehydrogenase virus infection prevents development of anti-nuclear antibody in (NZB x NZW)F1 mice; role of prostaglandin E2 and macrophage Ia antigen expression



Lactic dehydrogenase virus infection prevents development of anti-nuclear antibody in (NZB x NZW)F1 mice; role of prostaglandin E2 and macrophage Ia antigen expression



International Journal of Experimental Pathology 73(5): 593-601



Persistent lactic dehydrogenase virus (LDV) infection prevents the development of antinuclear antibody (ANA) in (NZB times NZW)F1 mice. To assess the suppressive mechanisms, we focused on the role of the E series of prostaglandin (PGE), since previously we have shown enhanced production of PGE by macrophages from chronically LDV-infected mice. Treatment with PGE-2 suppressed ANA titres more markedly in non-infected mice than in LDV-infected mice.

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Accession: 008942288

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PMID: 1419777


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