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Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine


Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine



Journal of Neuroscience: the Official Journal of the Society for Neuroscience 18(14): 5456-5462



ISSN/ISBN: 0270-6474

PMID: 9651226

DOI: 10.1523/jneurosci.18-14-05456.1998

The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is enhanced in spatial extent, amplitude, cellular infiltrate, and interleukin (IL)-1beta and nerve growth factor (NGF) expression. Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1beta and NGF expression induced by CFA. These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia.

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Accession: 008952500

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