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Lipid peroxides in the polychemotherapy of cancer patients

Lipid peroxides in the polychemotherapy of cancer patients

Chemotherapy 40(1): 8-15

There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, dauno-rubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this study was to investigate whether cancer patients who underwent polychemotherapy (n = 44) show more signs of oxidative stress in plasma than a group of healthy controls (n = 52). As an index of free radical generation, plasma concentrations of thiobarbituric-acid-reactive substances (TBARS), well-accepted as markers for oxidative stress, were determined by fluorometric detection after separation by high-performance liquid chromatography. In 12 cases, the TBARS were measured both before and after a chemotherapy course. After chemotherapy, 10 of 12 patients showed a marked increase in plasma TBARS concentration compared to values measured before therapy (9.02 +- 1.84 nmol/ml (n = 12) vs. 11.58 +- 2.49 nmol/ml (n = 12); p = 0.002, t-test for paired observations). Tumor patients in general had significantly larger amounts of TBARS in plasma in comparison with a control group (mean 11.88 +- 3.51 nmol/ml (n = 44) vs. 7.51 +- 2.14 nmol/ml (n = 52); p lt 0.001, t test). Our results are evidence that repetitive polychemotherapy with radical-generating compounds may exceed the antioxidative capacities of cancer patients and may lead to oxidative stress.

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Accession: 008960014

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PMID: 8306820

DOI: 10.1159/000239163

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