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Long-term remission in severe lupus nephritis-spontaneous remission or therapy effect



Long-term remission in severe lupus nephritis-spontaneous remission or therapy effect



Aktuelle Rheumatologie 23(1): 22-25



We report on a female patient who is now 51 years of age and in whom swellings of the joint had occurred for the first time in the fall of 1978. She was hospitalised in August 1979 because of colicky kidney pain. Shortly after her hospitalisation, she had additionally generalised oedemas, submandibularly enlarged lymph nodes, inspiratory dyspnoea and reddish discouloured urine. Systemic lupus erythematosus with membranoproliferative glomerulonephritis and focal crescent formation was diagnosed on identifying a pleural and pericardial effusion via imaging methods, typical laboratory data and histology of a renal biopsy. After initial haemofiltration because of fluid lung due to acute renal insufficiency and repeated plasmapheresis, immunosuppressive therapy with Imurek was performed for 11 years until 1990 with complete remission of the nephritis, maintained until the patient was again referred to us in April 1996 because of symmetric polyarthritis with sole administration of steroids. Lupus-associated polyarthritis was brought well under control by means of low-dose methotrexate therapy combined with 6 mg Urbason.

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Accession: 008971930

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