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Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis



Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis



Journal Of The American Academy Of Dermatology. 35(2 Part 1): 201



Background: Topical immunotherapy has been used in the treatment of children with alopecia areata with encouraging results. Objective: Our purpose was to determine the long-term results in 33 children with severe alopecia areata treated with topical immunotherapy. Methods: From 1983 to 1989 we treated 33 children with topical immunotherapy with squaric acid dibutylester. Results: Complete hair regrowth was observed in 10 children (30.3%). During the follow-up period (mean, 5.9 years; range, 4 to 12 years), 7 of these 10 patients had severe relapses that were not responsive to further treatment. Only three clinically benefitted from topical immunotherapy. Two maintained complete hair regrowth after treatment was stopped. Conclusion: Our results indicate that only a small proportion of children with severe alopecia areata will obtain a persistent benefit from topical immunotherapy.

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Accession: 008972228

Download citation: RISBibTeXText

PMID: 8708020

DOI: 10.1016/s0190-9622(96)90323-0



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